Bronaugh R L, Weingarten D P, Lowe N J
J Invest Dermatol. 1986 Oct;87(4):451-3. doi: 10.1111/1523-1747.ep12455487.
A monkey (Macaca fascicularis), diagnosed as having eczematous dermatitis on the basis of histopathology of a skin biopsy, was used to study the percutaneous absorption of 2 anti-inflammatory steroids. Absorption was measured through involved and uninvolved skin by using in vitro diffusion cell techniques. Hydrocortisone (0.5%) and triamcinolone acetonide (0.1%) were applied to the skin in a petrolatum vehicle. After application for 24 h, the permeation of hydrocortisone was approximately doubled (from 2.6 to 5.5% of the applied dose) when diseased skin was used. The absorption of triamcinolone acetonide was enhanced through the eczematous skin during the initial 12 h. At 24 h, however, no significant difference in total absorption was obtained.
一只根据皮肤活检组织病理学诊断为患有湿疹性皮炎的食蟹猴（Macaca fascicularis）被用于研究两种抗炎类固醇的经皮吸收情况。通过使用体外扩散池技术，测量了炎症皮肤和未受累皮肤的吸收情况。将氢化可的松（0.5%）和曲安奈德（0.1%）以凡士林为载体涂抹于皮肤上。给药24小时后，使用患病皮肤时，氢化可的松的渗透量大约增加了一倍（从给药剂量的2.6%增至5.5%）。在最初的12小时内，曲安奈德通过湿疹皮肤的吸收有所增强。然而，在24小时时，总吸收量没有显著差异。
