Schaefer H, Zesch A, Stüttgen G
Arch Dermatol Res (1975). 1977 May 27;258(3):241-9. doi: 10.1007/BF00561126.
Penetration studies of radiolabelled Triamcinolone acetonide from ointment or cream preparations revealed that in cases of normal as well as psoriatic skin 70-90% of the applied substance remains on the surface. Normal horny layer stores up to 30% of the steroid. Nevertheless, a rapid penetration into the living layers of the skin is observed, whereby the epidermal concentrations reach levels between 5-10(-6) and 3-10(-5) M (mol per liter of tissue). The excretion in the urine took more than 72 h after removal of the excess of substance from the skin. In psoriatic skin, the epidermal and dermal concentrations were 3-10 times higher than in normal skin. This increase lies in the same range as the one resulting from removal of the horny layer by stripping prior to the application, as reported earlier.
对放射性标记的曲安奈德从软膏或乳膏制剂中的渗透研究表明，在正常皮肤以及银屑病皮肤的情况下，70 - 90%的施用物质残留在表面。正常角质层可储存高达30%的类固醇。然而，观察到其能迅速渗透到皮肤的活性层，表皮浓度达到5×10⁻⁶至3×10⁻⁵摩尔/升（每升组织中的摩尔数）之间的水平。从皮肤去除多余物质后，尿液排泄持续超过72小时。在银屑病皮肤中，表皮和真皮浓度比正常皮肤高3 - 10倍。如先前报道，这种增加与施用前通过剥脱去除角质层所导致的增加幅度处于同一范围。
