Hansen Niels
Department of Psychiatry and Psychotherapy, University Medical Center Göttingen, Von-Siebold-Str. 5, 37075 Göttingen, Germany.
Antibodies (Basel). 2023 Jul 27;12(3):49. doi: 10.3390/antib12030049.
(1) Background: In this narrative review, we focus on neural autoantibodies in patients with coronavirus disease 2019 (COVID-19) as a consequence of severe acute respiratory syndrome coronavirus type 2 infection and persisting symptoms of post-COVID-19 syndrome with a psychiatric presentation. (2) Methods: Our methods include using the PubMed database to search for appropriate articles. (3) Results: We first describe the phenomenon of the psychiatric manifestation of COVID-19 in acute and persistent forms, associated with neural autoantibodies, often attributable to encephalopathy or encephalitis. We discuss the spectrum of neural autoantibodies in neuropsychiatric patients affected by COVID-19 and post-COVID-19 syndrome. Evidence from our research suggests that it is highly likely that neural autoantibody production is facilitated by SARS-CoV-2 infection, and that more neuropsychiatric patients than control subjects will present neural autoantibodies. (4) Conclusions: These observations support the hypothesis that acute and persisting forms of COVID-19 promote autoimmune diseases. Our patients therefore require comprehensive evaluation to avoid overlooking such autoantibody-associated psychiatric disorders associated with COVID-19.
（1）背景：在本叙述性综述中，我们关注2019冠状病毒病（COVID - 19）患者体内的神经自身抗体，这些抗体是严重急性呼吸综合征冠状病毒2型感染的结果，以及具有精神症状的COVID - 19后综合征的持续症状。（2）方法：我们的方法包括使用PubMed数据库搜索合适的文章。（3）结果：我们首先描述COVID - 19急性和持续形式的精神表现现象，其与神经自身抗体相关，常归因于脑病或脑炎。我们讨论了受COVID - 19和COVID - 19后综合征影响的神经精神疾病患者体内神经自身抗体的范围。我们的研究证据表明，SARS-CoV-2感染很可能促进神经自身抗体的产生，并且神经精神疾病患者出现神经自身抗体的人数将多于对照组。（4）结论：这些观察结果支持这样的假设，即COVID - 19的急性和持续形式会促进自身免疫性疾病。因此，我们的患者需要进行全面评估，以避免忽视与COVID - 19相关的此类自身抗体相关精神障碍。
