Rands G F
J Embryol Exp Morphol. 1986 Jun;94:139-48.
The development of mouse embryos formed by the aggregation of four 8-cell-stage eggs was analysed in comparison with control single embryos. The analysis revealed that: Quadruple aggregates undergo size regulation over several days, starting before implantation and being completed by 6.5 days post coitum. The attainment of recognizable postimplantation morphological stages is independent of size. Regulation is not brought about by disproportionate alterations in the size of the internal cavities. Regulation in both inner cell mass (ICM) and trophectoderm derivatives is completed between 5.5 and 6.5 days post coitum. Despite the abnormal proportions of ICM and trophectoderm in quadruple blastocysts, the proportions of the tissues derived from them are already normal by 5.5 days. The possibility that down regulation in size of aggregate embryos occurs as a consequence of limited nutrient supply is discussed.
将由四个8细胞期卵子聚集形成的小鼠胚胎发育与对照单胚胎进行了分析比较。分析结果显示：四倍聚集体在数天内进行大小调节，始于着床前并在交配后6.5天完成。达到可识别的着床后形态阶段与大小无关。调节并非由内腔大小的不成比例改变引起。内细胞团（ICM）和滋养外胚层衍生物的调节在交配后5.5至6.5天之间完成。尽管四倍胚泡中ICM和滋养外胚层比例异常，但由它们衍生的组织比例在5.5天时已恢复正常。文中讨论了聚集胚胎大小下调可能是营养供应有限所致的可能性。
