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[风疹感染后再感染与先天性多发性畸形综合征]

[Reinfection after rubella and congenital polymalformation syndrome].

作者信息

Sibille G, Sarda P, Jalaguier J, Eliaou J F, Montoya F, Bonnet H

出版信息

J Genet Hum. 1986 Aug;34(3-4):305-12.

PMID:3760833
Abstract

A case is reported of a term newborn with intra uterine growth retardation and numerous malformations such as complex heart disease, abnormalities of distal limbs, cleft palate. Death occurred after two days. The diagnosis of rubella embryopathy was confirmed by the following criteria: a high level of rubella antibodies in mother and newborn (1/1000) an isolation of rubella virus from the infant's urine. Diagnosis of rubella after reinfection was documented by a high level of antibodies in the mother three years before this pregnancy. Other observations reported in literature confirm the extreme rarity of congenital rubella after reinfection.

摘要

报道了一例足月儿,患有宫内生长迟缓以及多种畸形,如复杂性心脏病、四肢远端畸形、腭裂。患儿于两天后死亡。风疹胚胎病的诊断依据以下标准得以证实:母亲和新生儿体内风疹抗体水平较高(1/1000),且从婴儿尿液中分离出风疹病毒。此次妊娠三年前母亲体内抗体水平较高,证明其曾再次感染风疹。文献中报道的其他观察结果证实,再次感染后先天性风疹极为罕见。

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