Katschnig H, Straßmayr C, Endel F, Posch M, Steiner I
Department of Psychiatry, Medical University of Vienna, Vienna, Austria.
IMEHPS.research, Vienna, Austria.
Int J Methods Psychiatr Res. 2023 Aug 22;33(1):e1983. doi: 10.1002/mpr.1983.
Cost containment and quality of care considerations have increased research interest in the potential preventability of early re-hospitalisations. Various registry-based retrospective cohort studies on psychiatric re-hospitalisation have focused on the role of early post-discharge service contacts, but either did not consider their time-dependent nature ('immortal time bias') or evaded the issue by analysing late re-hospitalisations. The present study takes care of the immortal time bias in studying early psychiatric re-hospitalisations.
In a retrospective cohort study using nationwide electronic claims data in Austria, 10,689 adults discharged from acute psychiatric inpatient wards were followed up for 30 days. Cox regression analyses were performed with post-discharge psychiatric and general practitioner contacts as time-dependent covariates and time to first psychiatric re-hospitalisation as outcome.
Post-discharge ambulatory physician contacts were significantly associated with a decreased psychiatric re-hospitalisation rate (hazard ratio 0.77 [95% CI 0.69; 0.87], p < 0.0001), with similarly strong contributions to this association by general practitioners and psychiatrists.
Despite avoiding the immortal time bias and controlling for several confounders, we suggest to be cautious with a causal interpretation of the identified association, since potentially relevant confounders, such as disease severity, were unavailable in our claims data base.
成本控制和医疗质量考量增加了对早期再住院潜在可预防性的研究兴趣。各种基于登记处的精神科再住院回顾性队列研究都聚焦于出院后早期服务接触的作用,但要么未考虑其时间依赖性(“不朽时间偏倚”),要么通过分析晚期再住院来规避该问题。本研究在研究早期精神科再住院时考虑了不朽时间偏倚。
在一项使用奥地利全国电子索赔数据的回顾性队列研究中,对10689名从急性精神科住院病房出院的成年人进行了30天的随访。以出院后的精神科和全科医生接触作为时间依赖性协变量,以首次精神科再住院时间作为结局进行Cox回归分析。
出院后门诊医生接触与精神科再住院率降低显著相关(风险比0.77 [95%置信区间0.69;0.87],p < 0.0001),全科医生和精神科医生对该关联的贡献同样显著。
尽管避免了不朽时间偏倚并控制了多个混杂因素,但我们建议对所确定关联的因果解释持谨慎态度,因为我们的索赔数据库中没有疾病严重程度等潜在相关混杂因素。