Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands.
Department of Endocrinology, Leiden University Medical Center, Leiden, the Netherlands.
Eur J Endocrinol. 2021 Jan;184(1):E1-E4. doi: 10.1530/EJE-20-1124.
Immortal time bias should always be considered in an observational study if exposure status is determined based on a measurement or event that occurs after baseline. This bias can lead to an overestimation of an effect, but also to an underestimation, which is explained. Several approaches are illustrated that can be used to avoid immortal time bias in the analysis phase of the study; a time-dependent analysis to avoid immortal time bias optimizes the use of available information.
如果暴露状态是根据基线后发生的测量或事件确定的，则在观察性研究中应始终考虑到无寿命偏倚。这种偏倚可能导致效应高估，但也可能导致低估，对此进行了说明。文中还说明了几种可以在研究分析阶段避免无寿命偏倚的方法；避免无寿命偏倚的时依分析优化了对可用信息的利用。
