Department of Neurology, Martin-Luther-University Halle-Wittenberg, Halle (Saale), 06120, Germany.
Department of Radiotherapy, Martin-Luther-University Halle-Wittenberg, Halle (Saale), 06120, Germany.
Ann Clin Transl Neurol. 2023 Oct;10(10):1924-1930. doi: 10.1002/acn3.51878. Epub 2023 Aug 23.
We analyzed the longitudinal concentrations and prognostic roles of plasma β-synuclein (β-syn), glial fibrillary acidic protein (GFAP), and neurofilament proteins (NfL and NfH) in 33 patients with malignant gliomas, who underwent surgical and adjuvant therapy. GFAP and NfL levels were increased in patients with glioblastoma compared to cases with other tumors. β-syn, NfL and NfH increased after surgery, whereas GFAP decreased at long-term follow-up. β-syn and neurofilament concentrations were influenced by surgery and/or radiotherapy regimens. GFAP and neurofilament levels were significantly associated with survival. Plasma neuronal and astrocytic biomarkers are differentially altered in malignant glioma types and displayed distinct trajectories after surgical and adjuvant therapy.
我们分析了 33 名接受手术和辅助治疗的恶性胶质瘤患者的血浆β-突触核蛋白（β-syn）、神经胶质纤维酸性蛋白（GFAP）和神经丝蛋白（NfL 和 NfH）的纵向浓度及其预后作用。与其他肿瘤相比，胶质母细胞瘤患者的 GFAP 和 NfL 水平升高。β-syn、NfL 和 NfH 在手术后增加，而 GFAP 在长期随访中减少。β-syn 和神经丝浓度受手术和/或放疗方案的影响。GFAP 和神经丝水平与生存显著相关。血浆神经元和星形胶质细胞生物标志物在恶性胶质瘤类型中发生不同改变，并在手术和辅助治疗后呈现出不同的轨迹。
