Qin Jie, Jiang Chuanlu, Cai Jinquan, Meng Xiangqi
Department of Neurosurgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.
Front Oncol. 2021 Jun 11;11:688027. doi: 10.3389/fonc.2021.688027. eCollection 2021.
Accompanying the development of biomedicine, our knowledge of glioma, one of the most common primary intracranial carcinomas, is becoming more comprehensive. Unfortunately, patients with glioblastoma (GBM) still have a dismal prognosis and a high relapse rate, even with standard combination therapy, namely, surgical resection, postoperative radiotherapy and chemotherapy. The absence of validated biomarkers is responsible for the majority of these poor outcomes, and reliable therapeutic targets are indispensable for improving the prognosis of patients suffering from gliomas. Identification of both precise diagnostic and accurate prognostic markers and promising therapeutic targets has therefore attracted considerable attention from researchers. Encouragingly, accumulating evidence has demonstrated that long noncoding RNAs (lncRNAs) play important roles in the pathogenesis and oncogenesis of various categories of human tumors, including gliomas. Nevertheless, the underlying mechanisms by which lncRNAs regulate diverse biological behaviors of glioma cells, such as proliferation, invasion and migration, remain poorly understood. Consequently, this review builds on previous studies to further summarize the progress in the field of lncRNA regulation of gliomas over recent years and addresses the potential of lncRNAs as diagnostic and prognostic markers and therapeutic targets.
随着生物医学的发展，我们对神经胶质瘤（最常见的原发性颅内癌之一）的认识越来越全面。不幸的是，胶质母细胞瘤（GBM）患者的预后仍然很差，复发率很高，即使采用标准的联合治疗，即手术切除、术后放疗和化疗。缺乏经过验证的生物标志物是导致这些不良结果的主要原因，可靠的治疗靶点对于改善神经胶质瘤患者的预后不可或缺。因此，识别精确的诊断和准确的预后标志物以及有前景的治疗靶点引起了研究人员的广泛关注。令人鼓舞的是，越来越多的证据表明，长链非编码RNA（lncRNA）在包括神经胶质瘤在内的各类人类肿瘤的发病机制和肿瘤发生中发挥着重要作用。然而，lncRNA调节胶质瘤细胞多种生物学行为（如增殖、侵袭和迁移）的潜在机制仍知之甚少。因此，本综述基于以往的研究，进一步总结了近年来lncRNA对神经胶质瘤调控领域的进展，并探讨了lncRNA作为诊断和预后标志物以及治疗靶点的潜力。
