De Renzi E, Faglioni P, Scarpa M, Crisi G
J Neurol Neurosurg Psychiatry. 1986 Sep;49(9):1030-8. doi: 10.1136/jnnp.49.9.1030.
Limb apraxia was investigated with standardised tests in 14 patients whose CT scan provided evidence of a vascular lesion confined to the left basal ganglia, or the thalamus, or both, and not involving the cortex or adjacent white matter. Five patients were severely impaired in imitating movements and pantomiming object use. Four of them also performed poorly when tested with real objects. In two patients the lesion was primarily thalamic and in three the lesion was primarily in the lenticular nucleus and the posterior limb of the internal capsule. Patients without apraxia generally had smaller injuries, but there were exceptions. Apraxia is currently conceived of as due to damage of cortical areas and their cortico-cortical connections, but the present data suggest that the model should be enlarged to include the deep nuclei and the pathways running through them.
我们使用标准化测试对14例患者的肢体失用症进行了研究，这些患者的CT扫描显示血管病变局限于左侧基底神经节、丘脑或两者，且未累及皮质或相邻白质。5例患者在模仿动作和比划使用物体时严重受损。其中4例在使用真实物体进行测试时表现也很差。2例患者的病变主要在丘脑，3例患者的病变主要在豆状核和内囊后肢。没有失用症的患者损伤通常较小，但也有例外。目前认为失用症是由于皮质区域及其皮质 - 皮质连接受损所致，但目前的数据表明，该模型应扩大到包括深部核团及其之间的传导通路。
