Efficacy of Minocycline for the Treatment of .

BACKGROUND

High levels of macrolide resistance and increasing fluoroquinolone resistance are making increasingly difficult to treat. Minocycline is an alternative treatment for patients with macrolide-resistant infections that have failed moxifloxacin, or for those with fluoroquinolone contraindications or resistance. Published efficacy data for minocycline for are limited.

METHODS

We evaluated minocycline 100 mg twice daily for 14 days at Melbourne Sexual Health Centre (MSHC). Microbial cure was defined as a negative test of cure within 14-90 days after completing minocycline. The proportion cured and 95% confidence intervals (CIs) were calculated, and logistic regression was used to explore factors associated with treatment failure. We pooled data from the current study with a prior adjacent case series of patients with who had received minocycline 100 mg twice daily for 14 days at MSHC.

RESULTS

Minocycline cured 60 of 90 (67% [95% CI, 56%-76%]) infections. Adherence was high (96%) and side effects were mild and self-limiting. No demographic or clinical characteristics were associated with minocycline failure in regression analyses. In the pooled analyses of 123 patients, 83 (68% [95% CI, 58%-76%]) were cured following minocycline.

CONCLUSIONS

Minocycline cured 68% of macrolide-resistant infections. These data provide tighter precision around the efficacy of minocycline for macrolide-resistant and show that it is a well-tolerated regimen. With high levels of macrolide resistance, increasing fluoroquinolone resistance, and the high cost of moxifloxacin, access to nonquinolone options such as minocycline is increasingly important for the clinical management of .