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分子变态反应学及其在预防、诊断和治疗中的应用。

Molecular allergology and its application in prevention, diagnosis and therapy.

作者信息

Podzhilkova Aleksandra, Nagl Christoph, Hoffmann-Sommergruber Karin

机构信息

Institute of Pathophysiology and Allergy Research, Center of Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.

出版信息

Front Allergy. 2023 Aug 7;4:1260902. doi: 10.3389/falgy.2023.1260902. eCollection 2023.

DOI:10.3389/falgy.2023.1260902
PMID:37608929
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10441244/
Abstract

Allergic diseases represent a relevant global health problem, affecting adults and children and posing a significant burden for health care systems. In addition, the disease is still under-recognized and harmonized diagnostic tools and management plans for patients are still lacking. In this review the most important aspects of the diagnosis of allergic diseases are summarized and the contribution of Molecular allergology to this area is highlighted.

摘要

过敏性疾病是一个全球性的重大健康问题,影响着成人和儿童,给医疗保健系统带来了沉重负担。此外,该疾病仍未得到充分认识,针对患者的统一诊断工具和管理方案仍然缺乏。在这篇综述中,总结了过敏性疾病诊断的最重要方面,并强调了分子过敏学在该领域的贡献。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d8ea/10441244/5dd4deb10323/falgy-04-1260902-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d8ea/10441244/5dd4deb10323/falgy-04-1260902-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d8ea/10441244/5dd4deb10323/falgy-04-1260902-g001.jpg

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本文引用的文献

1
EAACI Molecular Allergology User's Guide 2.0.欧洲变态反应和临床免疫学会分子变态反应学用户指南2.0
Pediatr Allergy Immunol. 2023 Mar;34 Suppl 28:e13854. doi: 10.1111/pai.13854.
2
Peanut lipids influence the response of bronchial epithelial cells to the peanut allergens Ara h 1 and Ara h 2 by decreasing barrier permeability.花生脂质通过降低屏障通透性来影响支气管上皮细胞对花生过敏原Ara h 1和Ara h 2的反应。
Front Mol Biosci. 2023 Feb 8;10:1126008. doi: 10.3389/fmolb.2023.1126008. eCollection 2023.
3
pH-dependent structural diversity of profilin allergens determines thermal stability.
原肌球蛋白过敏原的pH依赖性结构多样性决定了热稳定性。
Front Allergy. 2022 Oct 17;3:1007000. doi: 10.3389/falgy.2022.1007000. eCollection 2022.
4
Basophil Activation Test With Aspergillus Molecules: The Case for ABPA.曲霉分子嗜碱性粒细胞激活试验:变应性支气管肺曲霉病的情况
Front Allergy. 2022 Jun 22;3:898731. doi: 10.3389/falgy.2022.898731. eCollection 2022.
5
Gibberellin-regulated proteins: Emergent allergens.赤霉素调节蛋白:新出现的过敏原。
Front Allergy. 2022 Sep 9;3:877553. doi: 10.3389/falgy.2022.877553. eCollection 2022.
6
Tree nut allergy: a systematic review.坚果过敏:系统评价。
Curr Opin Pediatr. 2022 Dec 1;34(6):600-608. doi: 10.1097/MOP.0000000000001180. Epub 2022 Sep 21.
7
Mammalian derived lipocalin and secretoglobin respiratory allergens strongly bind ligands with potentially immune modulating properties.哺乳动物源性脂钙蛋白和分泌球蛋白呼吸道过敏原能强烈结合具有潜在免疫调节特性的配体。
Front Allergy. 2022 Aug 4;3:958711. doi: 10.3389/falgy.2022.958711. eCollection 2022.
8
Linear Epitope Binding Patterns of Grass Pollen-Specific Antibodies in Allergy and in Response to Allergen-Specific Immunotherapy.草花粉特异性抗体在过敏及变应原特异性免疫治疗反应中的线性表位结合模式
Front Allergy. 2022 Mar 31;3:859126. doi: 10.3389/falgy.2022.859126. eCollection 2022.
9
The Allergen-Specific IgE Concentration Is Important for Optimal Histamine Release From Passively Sensitized Basophils.变应原特异性IgE浓度对于被动致敏嗜碱性粒细胞的最佳组胺释放很重要。
Front Allergy. 2022 Apr 7;3:875119. doi: 10.3389/falgy.2022.875119. eCollection 2022.
10
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Front Allergy. 2022 Feb 25;3:822554. doi: 10.3389/falgy.2022.822554. eCollection 2022.