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本文引用的文献

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Tiapride in the treatment of Huntington's chorea.硫必利治疗亨廷顿舞蹈病
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2
[Clinical trial of tiapride in patients with dyskinesia (author's transl)].
Sem Hop. 1982 Mar 25;58(12):725-33.
3
[Tiapride in the treatment of neurological and psychiatric disorders in the elderly (author's transl)].硫必利治疗老年人神经和精神疾病（作者译）
Sem Hop. 1981;57(43-44):1833-6.
4
Quantification of choreatic movements by Doppler radar.用多普勒雷达对舞蹈样动作进行量化。
Acta Neurol Scand. 1982 Sep;66(3):363-8. doi: 10.1111/j.1600-0404.1982.tb06857.x.
5
[Use of tiapride in persistent tardive dyskinesia following treatment with neuroleptics].
MMW Munch Med Wochenschr. 1983 May 27;125(21):461-2.
6
Tiapride in the treatment of tardive dyskinesia.
Acta Neurol Scand. 1982 Jan;65(1):38-44. doi: 10.1111/j.1600-0404.1982.tb03059.x.
7
Effects of tiapride in tardive dyskinesia.舒必利治疗迟发性运动障碍的效果。
Psychopharmacology (Berl). 1985;85(2):236-9. doi: 10.1007/BF00428422.

迟发性运动障碍患者中舒必利治疗范围的评估。

Assessment of the therapeutic range of tiapride in patients with tardive dyskinesia.

作者信息

Roos R A, Van der Velde E A, Buruma O J, de Wolff F A

出版信息

J Neurol Neurosurg Psychiatry. 1986 Sep;49(9):1055-8. doi: 10.1136/jnnp.49.9.1055.

DOI:10.1136/jnnp.49.9.1055
PMID:3760895
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1029012/
Abstract

Ten patients with tardive dyskinesia were treated with tiapride at an increasing dosage to establish the dose-concentration relationship and the dose-effect relationship. The effect was scored with the Abnormal Involuntary Movement Scale (AIMS) and the Doppler-radar method. The intra individual dosage-serum concentration correlation coefficients varied from 0.86 to 0.99 and the slopes of the individual regression lines varied from 0.16 to 0.58. All patients showed a diminution of their involuntary movements during the treatment period. A negative correlation coefficient was found between the dosage of tiapride and the AIMS; range -0.22 till -0.93, mean: -0.65 +/- 0.23 (SD). The Doppler-radar method results were inconclusive. No side-effects were observed.

摘要

对10例迟发性运动障碍患者使用硫必利进行治疗，剂量逐渐增加，以建立剂量-浓度关系和剂量-效应关系。采用异常不自主运动量表（AIMS）和多普勒雷达法对疗效进行评分。个体内剂量-血清浓度相关系数在0.86至0.99之间，个体回归线斜率在0.16至0.58之间。所有患者在治疗期间不自主运动均减少。硫必利剂量与AIMS之间存在负相关系数；范围为-0.22至-0.93，平均值：-0.65±0.23（标准差）。多普勒雷达法的结果尚无定论。未观察到副作用。