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新鲜骨折:同种异体骨使用的新指征——一项10年数据分析

Fresh Fractures: A New Indication for Use of Bone Allografts-A 10-Year Data Analysis.

作者信息

Galagali Dev Anand, Bhatia Aanchal, Kumar P Ashok, Ajoy S M

机构信息

Department of Orthopaedics, Ramaiah Medical College and Hospitals, Mathikere, Bangalore, Karnataka 560054 India.

出版信息

Indian J Orthop. 2023 Jul 20;57(9):1490-1496. doi: 10.1007/s43465-023-00953-z. eCollection 2023 Sep.

DOI:10.1007/s43465-023-00953-z
PMID:37609015
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10441971/
Abstract

BACKGROUND

Tissue banking includes the process starting from procurement to the distribution and usage of allograft tissues. The use of bone bank in orthopaedics is not widely seen. Our objective is to describe the 10-year allograft donor and recipient data from a fully functioning tissue bank in India, analyse the types of grafts used, indications and demand for various grafts. This will show the need for a tissue bank in a tertiary care orthopaedic setup.

METHODS

Analysis of donor and recipient data for allografts of a tissue bank in an Indian tertiary care setup was done from 2012 to 2022. The number of grafts procured and used were analysed. The recipient and donor sites were also analysed.

RESULTS

In 10 years, the tissue bank provided 2776 grafts and received 1962 donations. Slices procured after total knee replacements were the most commonly used allografts (28.03%). Acute fracture with bone loss or severe comminution (23.11%) being the most common indication of bone grafting was a major result of our study. Among these, proximal tibia (27.79%) was the most frequent recipient site. Tissue bank has also served patients in neurosurgery, ophthalmology, oromaxillofacial surgery, otorhinolaryngology, urology and wound care.

CONCLUSION

A tissue bank is a useful setup in tertiary care orthopaedic hospitals. Allografts were most widely used for acute trauma management. Allografts provide large graft quantity and reduce surgical time. Hence a tissue bank is not only an asset to the establishment but also to the surrounding hospitals, to which the grafts can be supplied.

摘要

背景

组织库涵盖了从同种异体组织的获取到分发及使用的整个过程。骨库在骨科领域的应用并不广泛。我们的目的是描述印度一家运作良好的组织库10年的同种异体组织供体和受体数据,分析所使用移植物的类型、适应症以及对各种移植物的需求。这将显示在三级骨科医疗环境中建立组织库的必要性。

方法

对印度一家三级医疗机构中一个组织库2012年至2022年的同种异体移植物供体和受体数据进行分析。分析获取和使用的移植物数量。同时也对受体和供体部位进行分析。

结果

在10年时间里,该组织库提供了2776份移植物,接收了1962份捐赠。全膝关节置换术后获取的切片是最常用的同种异体移植物(28.03%)。骨移植最常见的适应症是伴有骨缺损或严重粉碎的急性骨折(23.11%),这是我们研究的一个主要结果。其中,胫骨近端(27.79%)是最常见的受体部位。该组织库还为神经外科、眼科、口腔颌面外科、耳鼻喉科、泌尿外科和伤口护理的患者提供服务。

结论

组织库在三级骨科医院是一个有用的设施。同种异体移植物在急性创伤管理中应用最为广泛。同种异体移植物可提供大量移植物并减少手术时间。因此,组织库不仅是该机构的一项资产,对周边可供应移植物的医院也是如此。

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本文引用的文献

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Allograft versus autograft for reconstruction after resection of primary bone tumors: a comparative study of long-term clinical outcomes and risk factors for failure of reconstruction.同种异体移植物与自体移植物用于原发性骨肿瘤切除后重建:长期临床结果比较研究及重建失败的风险因素。
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Infection and utilization rates of bone allografts in a hospital-based musculoskeletal tissue bank in north India.印度北部一家医院肌肉骨骼组织库中同种异体骨移植的感染率和利用率
J Clin Orthop Trauma. 2021 Oct 15;23:101635. doi: 10.1016/j.jcot.2021.101635. eCollection 2021 Dec.
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India Joining the World of Hip and Knee Registries: Present Status-A Leap Forward.印度加入髋关节和膝关节注册领域:现状——向前迈进的一步
Indian J Orthop. 2020 Sep 16;55(Suppl 1):46-55. doi: 10.1007/s43465-020-00251-y. eCollection 2021 May.
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The choice between allograft or demineralized bone matrix is not unambiguous in trauma surgery.在创伤外科中,同种异体移植物或脱矿骨基质的选择并不明确。
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Comparisons of Efficacy between Autograft and Allograft on Defect Repair in Normal and Osteoporotic Rats.自体移植物与同种异体移植物在正常和骨质疏松大鼠缺损修复中的疗效比较。
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Midterm Results of Radiographic and Functional Outcomes After Tibiotalocalcaneal Arthrodesis With Bulk Femoral Head Allograft.使用大块股骨头同种异体骨进行胫距跟关节融合术后的影像学和功能结果中期报告
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The Role of Allograft Bone in Foot and Ankle Arthrodesis and High-Risk Fracture Management.同种异体骨在足踝关节融合及高风险骨折治疗中的作用。
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Comparative Study of Proximal Tibia and Iliac Crest Bone Graft Donor Sites in Treatment of Orthopaedic Pathologies.近端胫骨与髂嵴骨移植供区在治疗骨科疾病中的对比研究
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"Decalcified Allograft in Repair of Lytic Lesions of Bone": A Study to Evolve Bone Bank in Developing Countries.“脱钙异体骨修复骨溶解性病变”:发展中国家骨库发展的一项研究
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