华盛顿大学泰勒家族研究所：精神病学的新疗法。
The Taylor Family Institute at Washington University: Novel Treatments in Psychiatry.
机构信息
Professor, Department of Psychiatry, and the Taylor Family Institute for Innovative Psychiatric Research and Silvio O. Conte Neuroscience Center at Washington University School of Medicine, St. Louis, Missouri.
出版信息
Mo Med. 2023 Jul-Aug;120(4):299-305.
Abstract
Efforts to develop more effective treatments for psychiatric illnesses will require innovative approaches that address changes in brain networks underlying cognition, emotion and motivation, cardinal symptoms that cut across all psychiatric disorders. This effort will include new molecular entities that modulate neuronal excitability, synapses, cellular stress and inflammation. Other opportunities will come from repurposing existing treatments. This overview highlights current and future goals in treatment development in the Taylor Family Institute for Innovative Psychiatric Research at Washington University.
摘要
为精神疾病开发更有效的治疗方法需要创新的方法，以解决认知、情感和动机的大脑网络变化，这些是贯穿所有精神障碍的主要症状。这一努力将包括调节神经元兴奋性、突触、细胞应激和炎症的新分子实体。其他机会将来自于重新利用现有的治疗方法。这篇综述强调了华盛顿大学泰勒家庭创新精神病学研究所目前和未来的治疗开发目标。
相似文献
1
The Taylor Family Institute at Washington University: Novel Treatments in Psychiatry.华盛顿大学泰勒家族研究所：精神病学的新疗法。
Mo Med. 2023 Jul-Aug;120(4):299-305.
2
Smoking cessation medicines and e-cigarettes: a systematic review, network meta-analysis and cost-effectiveness analysis.戒烟药物和电子烟：系统评价、网络荟萃分析和成本效益分析。
Health Technol Assess. 2021 Oct;25(59):1-224. doi: 10.3310/hta25590.
3
"A Good Transition Is Just Key": The Views and Experiences of Disability Support Staff in Supporting Autistic Students Transition to University.“良好的过渡是关键”：残疾支持人员在支持自闭症学生过渡到大学方面的观点和经验。
Autism Adulthood. 2024 Jul 3;7(2):155-170. doi: 10.1089/aut.2024.0076. eCollection 2025 Apr.
4
Systemic pharmacological treatments for chronic plaque psoriasis: a network meta-analysis.系统性药理学治疗慢性斑块状银屑病：网络荟萃分析。
Cochrane Database Syst Rev. 2021 Apr 19;4(4):CD011535. doi: 10.1002/14651858.CD011535.pub4.
5
Systemic pharmacological treatments for chronic plaque psoriasis: a network meta-analysis.慢性斑块状银屑病的全身药理学治疗：一项网状Meta分析。
Cochrane Database Syst Rev. 2020 Jan 9;1(1):CD011535. doi: 10.1002/14651858.CD011535.pub3.
6
The effectiveness of ayurvedic oil-based nasal instillation (Nasya) medicines in the treatment of facial paralysis (Ardita): a systematic review.阿育吠陀油基滴鼻剂（Nasya）药物治疗面瘫（Ardita）的有效性：一项系统评价。
JBI Database System Rev Implement Rep. 2016 Apr;14(4):198-228. doi: 10.11124/JBISRIR-2016-2402.
7
Psychological interventions for parents of children and adolescents with chronic illness.针对患有慢性病的儿童和青少年家长的心理干预措施。
Cochrane Database Syst Rev. 2012 Aug 15;8(8):CD009660. doi: 10.1002/14651858.CD009660.pub2.
8
Home treatment for mental health problems: a systematic review.心理健康问题的居家治疗：一项系统综述
Health Technol Assess. 2001;5(15):1-139. doi: 10.3310/hta5150.
9
Feasibility study of Learning Together for Mental Health: fidelity, reach and acceptability of a whole-school intervention aiming to promote health and wellbeing in secondary schools.“共同学习促进心理健康”可行性研究：一项旨在促进中学健康与幸福的全校性干预措施的保真度、覆盖面和可接受性。
Public Health Res (Southampt). 2025 Jun 18:1-36. doi: 10.3310/RTRT0202.
10
Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE) for the early diagnosis of dementia across a variety of healthcare settings.老年人认知功能减退知情者问卷（IQCODE），用于在各种医疗环境中对痴呆进行早期诊断。
Cochrane Database Syst Rev. 2016 Nov 21;11(11):CD011333. doi: 10.1002/14651858.CD011333.pub2.
本文引用的文献
1
Nitrous Oxide, a Rapid Antidepressant, Has Ketamine-like Effects on Excitatory Transmission in the Adult Hippocampus.一氧化二氮，一种快速抗抑郁药，对成年海马体中的兴奋性传递具有类似氯胺酮的作用。
Biol Psychiatry. 2022 Dec 15;92(12):964-972. doi: 10.1016/j.biopsych.2022.06.016. Epub 2022 Jun 22.
2
The Enantiomer of Allopregnanolone Prevents Pressure-Mediated Retinal Degeneration Via Autophagy.别孕烯醇酮对映体通过自噬预防压力介导的视网膜变性。
Front Pharmacol. 2022 Mar 16;13:855779. doi: 10.3389/fphar.2022.855779. eCollection 2022.
3
Opportunities for Drug Repurposing of Serotonin Reuptake Inhibitors: Potential Uses in Inflammation, Infection, Cancer, Neuroprotection, and Alzheimer's Disease Prevention.重新利用血清素再摄取抑制剂的机会：在炎症、感染、癌症、神经保护和预防老年痴呆症中的潜在用途。
Pharmacopsychiatry. 2022 Jan;55(1):24-29. doi: 10.1055/a-1686-9620. Epub 2021 Dec 7.
4
A Proinflammatory Stimulus Disrupts Hippocampal Plasticity and Learning via Microglial Activation and 25-Hydroxycholesterol.促炎刺激通过小胶质细胞激活和 25-羟胆固醇破坏海马可塑性和学习能力。
J Neurosci. 2021 Dec 8;41(49):10054-10064. doi: 10.1523/JNEUROSCI.1502-21.2021. Epub 2021 Nov 1.
5
Effect of Zuranolone vs Placebo in Postpartum Depression: A Randomized Clinical Trial.Zuranolone 与安慰剂治疗产后抑郁症的随机临床试验。
JAMA Psychiatry. 2021 Sep 1;78(9):951-959. doi: 10.1001/jamapsychiatry.2021.1559.
6
A phase 2 trial of inhaled nitrous oxide for treatment-resistant major depression.一项关于吸入一氧化二氮治疗难治性重度抑郁症的 2 期临床试验。
Sci Transl Med. 2021 Jun 9;13(597). doi: 10.1126/scitranslmed.abe1376.
7
Effects of CYP46A1 Inhibition on Long-Term-Depression in Hippocampal Slices and 24S-Hydroxycholesterol Levels in Mice .CYP46A1抑制对小鼠海马切片长期抑郁及24S-羟基胆固醇水平的影响
Front Mol Neurosci. 2020 Oct 29;13:568641. doi: 10.3389/fnmol.2020.568641. eCollection 2020.
8
Fluvoxamine vs Placebo and Clinical Deterioration in Outpatients With Symptomatic COVID-19: A Randomized Clinical Trial.氟伏沙明对比安慰剂在伴有症状的 COVID-19 门诊患者中的临床恶化：一项随机临床试验。
JAMA. 2020 Dec 8;324(22):2292-2300. doi: 10.1001/jama.2020.22760.
9
Allopregnanolone in postpartum depression: Role in pathophysiology and treatment.别孕烯醇酮在产后抑郁症中的作用：在病理生理学及治疗中的角色
Neurobiol Stress. 2020 Feb 3;12:100212. doi: 10.1016/j.ynstr.2020.100212. eCollection 2020 May.
10
The neurosteroid allopregnanolone protects retinal neurons by effects on autophagy and GABRs/GABA receptors in rat glaucoma models.在大鼠青光眼模型中，神经甾体别孕烯醇酮通过对自噬以及GABRs/γ-氨基丁酸受体的作用来保护视网膜神经元。
Autophagy. 2021 Mar;17(3):743-760. doi: 10.1080/15548627.2020.1731270. Epub 2020 Feb 27.
Zotero 插件