肿瘤细胞与短小棒状杆菌的主动特异性免疫疗法：一项I期研究。
Active specific immunotherapy with tumor cells and Corynebacterium parvum: a phase I study.
作者信息
McCune C S, Patterson W B, Henshaw E C
出版信息
Cancer. 1979 May;43(5):1619-23. doi: 10.1002/1097-0142(197905)43:5<1619::aid-cncr2820430509>3.0.co;2-o.
Autologous, irradiated (10,000 rads) tumor cells mixed with C. parvum were given as weekly intracutaneous injections to fifteen patients with residual malignant disease. The toxicity was minimal and distinctly less than has been seen with tumor cell-BCG immunotherapy. A goal of 4 injections of 10(7) cells each was possible in only 4 patients because of limitations in methods of disaggregation and quantity of tumor available. The feasibility aspects are discussed and a case report of a prolonged regression is presented.
将自体、经照射（10000拉德）的肿瘤细胞与微小隐孢子虫混合后，每周对15例残留恶性疾病患者进行皮内注射。毒性极小，明显低于肿瘤细胞-卡介苗免疫疗法所见的毒性。由于肿瘤解离方法和可用肿瘤数量的限制，只有4例患者能够实现每次注射10⁷个细胞、共注射4次的目标。本文讨论了可行性方面的问题，并给出了一例长期缓解的病例报告。
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