• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

小鼠中孕期诱导的病原体特异性T细胞从母体向胎儿的转移。

Pregnancy-induced transfer of pathogen-specific T cells from mother to fetus in mice.

作者信息

Yüzen Dennis, Urbschat Christopher, Schepanski Steven, Thiele Kristin, Arck Petra C, Mittrücker Hans-Willi

机构信息

Division of Experimental Feto-Maternal Medicine, Department of Obstetrics and Fetal Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Institute of Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

出版信息

EMBO Rep. 2023 Oct 9;24(10):e56829. doi: 10.15252/embr.202356829. Epub 2023 Aug 23.

DOI:10.15252/embr.202356829
PMID:37610043
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10561172/
Abstract

Neonatal health is determined by the transfer of maternal antibodies from the mother to the fetus. Besides antibodies, maternal cells cross the placental barrier and seed into fetal organs. Contrary to maternal antibodies, maternal microchimeric cells (MMc) show a high longevity, as they can persist in the offspring until adulthood. Recent evidence highlights that MMc leukocytes promote neonatal immunity against early-life infections in mice and humans. As shown in mice, this promotion of immunity was attributable to an improved fetal immune development. Besides this indirect effect, MMc may be pathogen-specific and thus, directly clear pathogen threats in the offspring postnatally. By using ovalbumin recombinant Listeria monocytogenes (LmOVA), we here provide evidence that OVA-specific T cells are transferred from the mother to the fetus, which is associated with increased activation of T cells and a milder course of postnatal infection in the offspring. Our data highlight that maternally-derived passive immunity of the neonate is not limited to antibodies, as MMc have the potential to transfer immune memory between generations.

摘要

新生儿健康取决于母体抗体从母亲向胎儿的转移。除了抗体，母体细胞会穿过胎盘屏障并植入胎儿器官。与母体抗体不同，母体微嵌合细胞（MMc）具有很长的寿命，因为它们可以在后代体内持续存在直至成年。最近的证据表明，MMc白细胞可促进小鼠和人类新生儿对早期感染的免疫。如在小鼠中所示，这种免疫促进作用归因于胎儿免疫发育的改善。除了这种间接作用外，MMc可能具有病原体特异性，因此可在产后直接清除后代体内的病原体威胁。通过使用卵清蛋白重组单核细胞增生李斯特菌（LmOVA），我们在此提供证据表明，OVA特异性T细胞从母亲转移至胎儿，这与后代T细胞的激活增加以及产后感染病程较轻有关。我们的数据突出表明，新生儿的母体来源被动免疫并不局限于抗体，因为MMc有潜力在代际之间传递免疫记忆。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51f7/10561172/c772081afd77/EMBR-24-e56829-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51f7/10561172/a25057024951/EMBR-24-e56829-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51f7/10561172/098e6e09a318/EMBR-24-e56829-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51f7/10561172/5de2786ad7c0/EMBR-24-e56829-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51f7/10561172/ff1f50bfa664/EMBR-24-e56829-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51f7/10561172/391ce15c1a6a/EMBR-24-e56829-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51f7/10561172/3c9234fa4b9c/EMBR-24-e56829-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51f7/10561172/c772081afd77/EMBR-24-e56829-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51f7/10561172/a25057024951/EMBR-24-e56829-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51f7/10561172/098e6e09a318/EMBR-24-e56829-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51f7/10561172/5de2786ad7c0/EMBR-24-e56829-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51f7/10561172/ff1f50bfa664/EMBR-24-e56829-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51f7/10561172/391ce15c1a6a/EMBR-24-e56829-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51f7/10561172/3c9234fa4b9c/EMBR-24-e56829-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51f7/10561172/c772081afd77/EMBR-24-e56829-g002.jpg

相似文献

1
Pregnancy-induced transfer of pathogen-specific T cells from mother to fetus in mice.小鼠中孕期诱导的病原体特异性T细胞从母体向胎儿的转移。
EMBO Rep. 2023 Oct 9;24(10):e56829. doi: 10.15252/embr.202356829. Epub 2023 Aug 23.
2
Vertically transferred maternal immune cells promote neonatal immunity against early life infections.垂直传递的母体免疫细胞促进新生儿抵御早期生命感染的免疫力。
Nat Commun. 2021 Aug 4;12(1):4706. doi: 10.1038/s41467-021-24719-z.
3
Maternal microchimerism: lessons learned from murine models.母源微嵌合体：从小鼠模型中获得的经验教训。
J Reprod Immunol. 2015 Apr;108:12-25. doi: 10.1016/j.jri.2014.12.007. Epub 2015 Jan 8.
4
Pregnancy-induced maternal microchimerism shapes neurodevelopment and behavior in mice.妊娠诱导的母体微嵌合体塑造了小鼠的神经发育和行为。
Nat Commun. 2022 Aug 5;13(1):4571. doi: 10.1038/s41467-022-32230-2.
5
Stem cell microchimerism and tolerance to non-inherited maternal antigens.干细胞微嵌合体与对非遗传母体抗原的耐受性
Chimerism. 2010 Jul-Sep;1(1):2-10. doi: 10.4161/chim.1.1.12667.
6
Balance between early life tolerance and sensitization in allergy: dependence on the timing and intensity of prenatal and postnatal allergen exposure of the mother.过敏症中早期耐受与致敏之间的平衡：取决于母亲产前和产后过敏原暴露的时间和强度。
Immunology. 2009 Sep;128(1 Suppl):e541-50. doi: 10.1111/j.1365-2567.2008.03028.x. Epub 2008 Dec 18.
7
Hofbauer Cells Spread Listeria monocytogenes among Placental Cells and Undergo Pro-Inflammatory Reprogramming while Retaining Production of Tolerogenic Factors.成纤维细胞样滋养层细胞在胎盘细胞间传播李斯特菌并发生促炎重编程，同时保留耐受原性因子的产生。
mBio. 2021 Aug 31;12(4):e0184921. doi: 10.1128/mBio.01849-21. Epub 2021 Aug 17.
8
Postnatal depletion of maternal cells biases T lymphocytes and natural killer cells' profiles toward early activation in the spleen.产后母体细胞耗竭使脾脏中 T 淋巴细胞和自然杀伤细胞的特征向早期激活偏移。
Biol Open. 2022 Nov 1;11(11). doi: 10.1242/bio.059334. Epub 2022 Nov 9.
9
Infant immunity against viral infections is advanced by the placenta-dependent vertical transfer of maternal antibodies.婴儿对病毒感染的免疫力是通过胎盘依赖的垂直传递母体抗体来实现的。
Vaccine. 2022 Mar 8;40(11):1563-1571. doi: 10.1016/j.vaccine.2020.12.049. Epub 2021 Jan 9.
10
Fetal microchimerism and the two-stage model of preeclampsia.胎儿微嵌合体与子痫前期的两阶段模型。
J Reprod Immunol. 2023 Sep;159:104124. doi: 10.1016/j.jri.2023.104124. Epub 2023 Jul 25.

引用本文的文献

1
The when, what, and where of naturally-acquired microchimerism.自然获得性微嵌合体的时间、内容和位置。
Semin Immunopathol. 2025 Mar 11;47(1):20. doi: 10.1007/s00281-024-01029-2.
2
Micro-to multi-chimerism: the multiple facets of a singular phenomenon.微嵌合到多嵌合：一种独特现象的多个方面。
Semin Immunopathol. 2025 Feb 18;47(1):17. doi: 10.1007/s00281-025-01044-x.
3
Maternal microchimeric cell trafficking and its biological consequences depend on the onset of inflammation at the feto-maternal interface.母源性微嵌合细胞的转运及其生物学后果取决于母胎界面炎症的发生。

本文引用的文献

1
Pregnancy enables antibody protection against intracellular infection.妊娠使机体针对细胞内感染产生抗体保护。
Nature. 2022 Jun;606(7915):769-775. doi: 10.1038/s41586-022-04816-9. Epub 2022 Jun 8.
2
Grandmaternal cells in cord blood.脐血中的祖细胞。
EBioMedicine. 2021 Dec;74:103721. doi: 10.1016/j.ebiom.2021.103721. Epub 2021 Nov 26.
3
Vertically transferred maternal immune cells promote neonatal immunity against early life infections.垂直传递的母体免疫细胞促进新生儿抵御早期生命感染的免疫力。
Semin Immunopathol. 2025 Jan 17;47(1):8. doi: 10.1007/s00281-025-01037-w.
4
Pregnancy induced displacement of preexisting microchimeric cells in the absence of maternal B and T cells.妊娠诱导母体内已存在的微嵌合细胞迁移，而不依赖于母体内的 B 和 T 细胞。
Front Immunol. 2024 Oct 30;15:1478465. doi: 10.3389/fimmu.2024.1478465. eCollection 2024.
5
Exposure to Human Immunodeficiency Virus Is Associated With Altered Composition of Maternal Microchimeric T Cells in Infants.暴露于人类免疫缺陷病毒与婴儿母体微嵌合T细胞组成的改变有关。
J Infect Dis. 2025 Feb 20;231(2):435-439. doi: 10.1093/infdis/jiae521.
6
Deciphering the Role of Maternal Microchimerism in Offspring Autoimmunity: A Narrative Review.解析母源性微小嵌合体在子代自身免疫中的作用：叙述性综述。
Medicina (Kaunas). 2024 Sep 5;60(9):1457. doi: 10.3390/medicina60091457.
7
From Womb to World: Exploring the Immunological Connections between Mother and Child.从子宫到世界：探索母婴之间的免疫联系。
Immunohorizons. 2024 Aug 1;8(8):552-562. doi: 10.4049/immunohorizons.2400032.
8
The 'communicatome' of pregnancy: spotlight on cellular and extravesicular chimerism.妊娠的“通讯组”：聚焦细胞和细胞外嵌合体。
EMBO Mol Med. 2024 Apr;16(4):700-714. doi: 10.1038/s44321-024-00045-x. Epub 2024 Mar 11.
Nat Commun. 2021 Aug 4;12(1):4706. doi: 10.1038/s41467-021-24719-z.
4
Distinct populations of antigen-specific tissue-resident CD8+ T cells in human cervix mucosa.人类宫颈黏膜中存在具有独特抗原特异性的组织驻留 CD8+T 细胞群体。
JCI Insight. 2021 Aug 9;6(15):e149950. doi: 10.1172/jci.insight.149950.
5
Cervicovaginal Tissue Residence Confers a Distinct Differentiation Program upon Memory CD8 T Cells.宫颈阴道组织驻留赋予记忆 CD8 T 细胞独特的分化程序。
J Immunol. 2021 Jun 15;206(12):2937-2948. doi: 10.4049/jimmunol.2100166. Epub 2021 Jun 4.
6
Circulating immunity protects the female reproductive tract from infection.循环免疫可保护女性生殖道免受感染。
Proc Natl Acad Sci U S A. 2021 May 25;118(21). doi: 10.1073/pnas.2104407118.
7
Impact of maternal engrafted cytomegalovirus-specific CD8 T cells in a patient with severe combined immunodeficiency.母体植入巨细胞病毒特异性CD8 T细胞对一名重症联合免疫缺陷患者的影响。
Clin Transl Immunology. 2021 Apr 13;10(4):e1272. doi: 10.1002/cti2.1272. eCollection 2021.
8
Infant immunity against viral infections is advanced by the placenta-dependent vertical transfer of maternal antibodies.婴儿对病毒感染的免疫力是通过胎盘依赖的垂直传递母体抗体来实现的。
Vaccine. 2022 Mar 8;40(11):1563-1571. doi: 10.1016/j.vaccine.2020.12.049. Epub 2021 Jan 9.
9
Forever Connected: The Lifelong Biological Consequences of Fetomaternal and Maternofetal Microchimerism.永远相连：胎母和母子微嵌合体的终生生物学后果。
Clin Chem. 2021 Jan 30;67(2):351-362. doi: 10.1093/clinchem/hvaa304.
10
Parenteral vaccination protects against transcervical infection with and generate tissue-resident T cells post-challenge.肠胃外接种疫苗可预防经宫颈感染，并在激发后产生组织驻留T细胞。
NPJ Vaccines. 2020 Jan 23;5(1):7. doi: 10.1038/s41541-020-0157-x. eCollection 2020.