Research Center for Marine Drugs, State Key Laboratory of Microbial Metabolism, Department of Pharmacy, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China.
School of Pharmaceutical Sciences, Xiamen University, Xiamen 361102, China.
Org Lett. 2023 Sep 1;25(34):6391-6395. doi: 10.1021/acs.orglett.3c02409. Epub 2023 Aug 23.
An unusual secomeroterpenoid, dysambiol (), was isolated from a sp. marine sponge collected from the South China Sea. Dysambiol features an unprecedented secomeroterpene scaffold with a rare lactone bridge. The structure of was determined by extensive spectroscopic analysis, Mosher's method, and electronic circular dichroism calculation. Dysambiol displayed potent anti-inflammatory activity in LPS-induced Raw 264.7 macrophages by regulating the NF-κB/MPAK signaling pathway.
从南海采集的一种 海绵中分离得到一种罕见的倍半萜类化合物 dysambiol()。该化合物具有一个前所未有的倍半萜骨架和一个罕见的内酯桥。通过广泛的光谱分析、Mosher 方法和电子圆二色性计算确定了 的结构。Dysambiol 通过调节 NF-κB/MPAK 信号通路，在 LPS 诱导的 Raw 264.7 巨噬细胞中显示出强大的抗炎活性。
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