双鞭甲藻素A，一种来自中国南海海绵Dysidea sp.的具有抗耐甲氧西林金黄色葡萄球菌活性的罕见半萜类化合物。
Dysidinoid A, an unusual meroterpenoid with anti-MRSA activity from the South China Sea sponge Dysidea sp.
作者信息
Jiao Wei-Hua, Li Jing, Liu Qian, Xu Ting-Ting, Shi Guo-Hua, Yu Hao-Bing, Yang Fan, Han Bing-Nan, Li Min, Lin Hou-Wen
机构信息
Key Laboratory for Marine Drugs, Department of Pharmacy, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200127, China.
Department of Clinical Laboratory, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200127, China.
出版信息
Molecules. 2014 Nov 5;19(11):18025-32. doi: 10.3390/molecules191118025.
An unusual meroterpenoid, dysidinoid A (1), was isolated from the South China Sea sponge Dysidea sp. Its structure was elucidated by extensive spectroscopic methods including HRESIMS and 2D NMR, and its absolute configuration was determined by single-crystal X-ray diffraction analysis. Dysidinoid A (1) is the first meroterpenoid from Nature bearing a 9,4-friedodrime skeleton and a 2,5-dionepyrrole unit. Dysidinoid A (1) showed potent antibacterial activity against two strains of pathogenic bacteria methicillin-resistant Staphylococcus aureus (MRSA) with MIC90 values of 8.0 μg/mL against both.
从中国南海海绵Dysidea属物种中分离出一种不寻常的半萜类化合物——dysidinoid A（1）。通过包括高分辨电喷雾电离质谱（HRESIMS）和二维核磁共振（2D NMR）在内的多种光谱方法阐明了其结构，并通过单晶X射线衍射分析确定了其绝对构型。Dysidinoid A（1）是自然界中首个具有9,4-二降卓烷骨架和2,5-二酮吡咯单元的半萜类化合物。Dysidinoid A（1）对两株耐甲氧西林金黄色葡萄球菌（MRSA）病原菌显示出强效抗菌活性，其MIC90值均为8.0 μg/mL。
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