Raymond Maggie J F, Rakotondraibe Harinantenaina L
Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH 43210, USA.
Molecules. 2025 Feb 28;30(5):1112. doi: 10.3390/molecules30051112.
Marine sponges are a promising source of bioactive secondary metabolites, contributing hundreds of novel compounds per year to natural product research, each with diverse chemical and biological properties. We have chosen to highlight marine natural products that exhibited unique structural features and/or significant bioactivity. The most common report of pharmacological significance was cytotoxicity, with antimicrobial and enzyme inhibition activities following, and mentions of other attributes, such as anti-inflammation, neuroprotection, and anti-biofilm. This review describes newly isolated constituents from sponges between 2020 and 2023 alongside their relevant pharmacological activity. The isolation, structures, and biological properties of 218 unique secondary metabolites from various chemical families, including terpenoids, peptides, and alkaloids from marine sponges, are covered.
海洋海绵是生物活性次生代谢产物的一个有前景的来源，每年为天然产物研究贡献数百种新化合物，每种化合物都具有多样的化学和生物学特性。我们选择重点介绍具有独特结构特征和/或显著生物活性的海洋天然产物。药理学意义最常见的报道是细胞毒性，其次是抗菌和酶抑制活性，以及其他属性的提及，如抗炎、神经保护和抗生物膜。本综述描述了2020年至2023年间从海绵中新分离出的成分及其相关药理活性。涵盖了来自各种化学家族的218种独特次生代谢产物的分离、结构和生物学特性，这些次生代谢产物包括来自海洋海绵的萜类化合物、肽类和生物碱。
