Ellerton J A, deVeber G A, Baker M A
Cancer. 1979 May;43(5):1924-6. doi: 10.1002/1097-0142(197905)43:5<1924::aid-cncr2820430551>3.0.co;2-b.
A 53-year-old male developed acute erythroleukemia three years after renal transplantation. He had received three years of immunosuppressive therapy with azathioprine. A preleukemia phase associated with chromosome abnormalities was recognized. Azathioprine has been associated with chromosome abnormalities. The chronic stimulation of an abnormal erythroid clone by transplantation may have hastened the development of erythroleukemia.
一名53岁男性在肾移植三年后患上急性红白血病。他接受了三年的硫唑嘌呤免疫抑制治疗。一个与染色体异常相关的白血病前期被识别出来。硫唑嘌呤一直与染色体异常有关。移植对异常红系克隆的慢性刺激可能加速了红白血病的发展。
