Stamberg J
Division of Human Genetics, Schneider Children's Hospital, Long Island Jewish Medical Center, New Hyde Park, New York 11042.
Cancer. 1987 Dec 1;60(11):2649-53. doi: 10.1002/1097-0142(19871201)60:11<2649::aid-cncr2820601113>3.0.co;2-f.
Erythroleukemia (EL) is a heterogeneous disease in terms of cell type affected, chromosome abnormalities found in the malignant clone, and clinical course. In this article, cases of erythroid EL from the recent medical literature are reviewed using cytogenetic criteria to distinguish such cases from those of myeloid EL. Although most patients with erythroid EL were elderly men, 20% of the cases occurred in the under-3 age group, where boys and girls were equally affected. Chromosomes 5 and 7 were found to be lost or partially deleted in two thirds of the adult patients only, but not in the pediatric patients; this suggests that EL is associated with cumulative mutagen exposure in adult patients only. It is proposed that cytogenetic criteria may be of use prospectively in distinguishing patients with erythroid EL from those with myeloid EL.
红白血病（EL）在受影响的细胞类型、恶性克隆中发现的染色体异常以及临床病程方面是一种异质性疾病。在本文中，使用细胞遗传学标准对近期医学文献中的红系EL病例进行了综述，以将此类病例与髓系EL病例区分开来。尽管大多数红系EL患者为老年男性，但20%的病例发生在3岁以下年龄组，该年龄组男女受影响程度相同。仅在三分之二的成年患者中发现5号和7号染色体丢失或部分缺失，而在儿科患者中未发现；这表明EL仅与成年患者累积的诱变剂暴露有关。有人提出，细胞遗传学标准可能在区分红系EL患者和髓系EL患者方面具有前瞻性用途。
