Department of Gastroenterology, Nizam's Institute of Medical Sciences, 4th Floor, Specialty Block, Panjagutta, Hyderabad, 500 082, India.
Department of Gastroenterology, K M Cherian Institute of Medical Sciences, Kallissery, 689 124, India.
Indian J Gastroenterol. 2023 Oct;42(5):629-641. doi: 10.1007/s12664-023-01400-5. Epub 2023 Aug 23.
Both Budd-Chiari syndrome (BCS) and portal vein thrombosis (PVT) have been linked to various prothrombotic (PT) conditions. The PT profile in Asians is different from the west and there are no nationwide epidemiological surveys from India. Hence, the present meta-analysis was aimed at analyzing the prevalence of acquired and hereditary thrombophilia among Indian patients with non-cirrhotic PVT and BCS.
A comprehensive literature search of Embase, Medline and Scopus was conducted from January 2000 to February 2022 for studies evaluating the prevalence of various PT conditions in Indian patients with PVT and BCS. Pooled prevalence rates across studies were expressed with summative statistics.
Thirty-five studies with 1005 PVT patients and 1391 BCS patients were included in the meta-analysis. At least one PT condition was seen in 46.2% (28.7-63.7) of the PVT patients and 44.9% (37.3-60.7) of the BCS patients. Multiple PT conditions were seen in 13.0% (4.2-21.8) of the PVT patients and 7.9% (3.5-12.4) of the BCS patients. Among PVT patients, hyperhomocysteinemia was the commonest prothrombotic condition (21.6%) followed by protein C (PC) deficiency (10.7%), Janus kinase 2 (JAK-2) mutation (8.5%) and antiphospholipid antibodies (APLA) (7.5%). Among patients with BCS, PC deficiency was the commonest prothrombotic condition (10.6%) followed by methylenetetrahydrofolate reductase (MTHFR) mutation (9.8%), APLA (9.7%) and JAK-2 mutation (9.1%).
The PT profile in Indian patients with abdominal vein thrombosis is different from that of the western data with a lower prevalence of PT conditions in patients with BCS.
布加综合征（BCS）和门静脉血栓形成（PVT）都与各种易栓症（PT）有关。亚洲人的 PT 特征与西方不同，印度也没有全国性的流行病学调查。因此，本荟萃分析旨在分析非肝硬化性 PVT 和 BCS 印度患者获得性和遗传性血栓形成倾向的患病率。
对 Embase、Medline 和 Scopus 进行了全面的文献检索，检索时间从 2000 年 1 月至 2022 年 2 月，以评估 PVT 和 BCS 印度患者中各种 PT 情况的患病率。汇总了研究中的患病率，采用总结性统计。
纳入了 35 项研究，其中 1005 例 PVT 患者和 1391 例 BCS 患者。至少有一种 PT 情况在 46.2%（28.7-63.7）的 PVT 患者和 44.9%（37.3-60.7）的 BCS 患者中可见。在 13.0%（4.2-21.8）的 PVT 患者和 7.9%（3.5-12.4）的 BCS 患者中可见多种 PT 情况。在 PVT 患者中，高同型半胱氨酸血症是最常见的易栓性疾病（21.6%），其次是蛋白 C（PC）缺乏症（10.7%）、Janus 激酶 2 突变（8.5%）和抗磷脂抗体（APLA）（7.5%）。在 BCS 患者中，PC 缺乏症是最常见的易栓性疾病（10.6%），其次是亚甲基四氢叶酸还原酶（MTHFR）突变（9.8%）、APLA（9.7%）和 JAK-2 突变（9.1%）。
印度腹部静脉血栓患者的 PT 特征与西方数据不同，BCS 患者的 PT 情况患病率较低。
