Ward S L, Jacobs R A, Gates E P, Hart L D, Keens T G
J Pediatr. 1986 Oct;109(4):631-4. doi: 10.1016/s0022-3476(86)80226-8.
Some infants with myelomeningocele, hydrocephalus, and Arnold-Chiari malformation have symptomatic apnea or hypoventilation. The incidence of abnormalities of the ventilatory pattern during sleep in asymptomatic infants with myelomeningocele is not known. Therefore we performed overnight pneumograms (recordings of ventilatory pattern and electrocardiogram) in 18 asymptomatic infants with myelomeningocele and compared them with pneumograms from 64 control infants. Infants with myelomeningocele had longer total sleep time (596 +/- 16 minutes vs 536 +/- 10 minutes, P less than 0.005), longer episodes of longest apnea (12.6 +/- 0.8 seconds vs 8.1 +/- 0.3 seconds, P less than 0.001), greater total duration of apnea greater than or equal to 6 seconds as percent total sleep time (1.02% +/- 0.18% vs 0.23% +/- 0.03%, P less than 0.001), and lower mean heart rates (120 +/- 5 vs 145 +/- 5, P less than 0.001) than did control infants. No abnormal bradycardia was observed in either group. Thirteen (72%) of 18 infants with myelomeningocele had abnormal pneumograms, compared with 4 (6%) of 64 control infants (P less than 0.0005). We conclude that asymptomatic infants with myelomeningocele have a high incidence of ventilatory pattern abnormalities during sleep.
一些患有脊髓脊膜膨出、脑积水和阿诺德-奇阿利畸形的婴儿有症状性呼吸暂停或通气不足。脊髓脊膜膨出无症状婴儿睡眠期间呼吸模式异常的发生率尚不清楚。因此，我们对18名脊髓脊膜膨出无症状婴儿进行了整夜呼吸描记图（记录呼吸模式和心电图），并将其与64名对照婴儿的呼吸描记图进行比较。脊髓脊膜膨出婴儿的总睡眠时间更长（596±16分钟对536±10分钟，P<0.005），最长呼吸暂停发作时间更长（12.6±0.8秒对8.1±0.3秒，P<0.001），呼吸暂停总时长占总睡眠时间的百分比更高（1.02%±0.18%对0.23%±0.03%，P<0.001），平均心率更低（120±5对145±5，P<0.001）。两组均未观察到异常心动过缓。18名脊髓脊膜膨出婴儿中有13名（72%）呼吸描记图异常，而64名对照婴儿中有4名（6%）异常（P<0.0005）。我们得出结论，脊髓脊膜膨出无症状婴儿睡眠期间呼吸模式异常的发生率很高。
