Kelly D H, Golub H, Carley D, Shannon D C
J Pediatr. 1986 Aug;109(2):249-54. doi: 10.1016/s0022-3476(86)80380-8.
Victims of sudden infant death syndrome (SIDS) have occasionally been reported to have had prolonged apnea or an increased frequency of short apnea prior to their deaths. To examine the extent of these abnormalities, we compared pneumograms obtained in 17 infants who subsequently died of SIDS (10 with history of apnea) with those of 34 age- and sex-matched controls. The recordings were analyzed by a computer program that avoided observer bias. SIDS infants had significantly greater mean heart rate (P less than 0.05) and periodic breathing during quiet time (P less than 0.003) than control infants had. The apnea in SIDS infants tended to be more periodic than in control infants (P less than 0.002). In addition, the incidence of bradycardia was greater in SIDS (three infants) than in controls (none) (P less than 0.03). These differences suggest a disturbance of autonomic function prior to death in some victims of SIDS.
据报道，婴儿猝死综合征（SIDS）的受害者在死亡前偶尔会出现呼吸暂停延长或短暂呼吸暂停频率增加的情况。为了研究这些异常情况的程度，我们将17名随后死于SIDS的婴儿（10名有呼吸暂停病史）的呼吸描记图与34名年龄和性别匹配的对照组婴儿的呼吸描记图进行了比较。这些记录由一个避免观察者偏差的计算机程序进行分析。与对照组婴儿相比，SIDS婴儿在安静时的平均心率明显更高（P<0.05），周期性呼吸更为明显（P<0.003）。SIDS婴儿的呼吸暂停比对照组婴儿更倾向于周期性（P<0.002）。此外，SIDS组（3名婴儿）心动过缓的发生率高于对照组（无）（P<0.03）。这些差异表明，一些SIDS受害者在死亡前存在自主神经功能紊乱。
