基于生物复合材料的牙科骨再生策略。
Biocomposite-based strategies for dental bone regeneration.
机构信息
School of Medicine and Dentistry, Griffith University, Gold Coast, Australia.
Immunology of Infectious Diseases Research Center, Research Institute of Basic Medical Sciences, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
出版信息
Oral Surg Oral Med Oral Pathol Oral Radiol. 2023 Nov;136(5):554-568. doi: 10.1016/j.oooo.2023.04.015. Epub 2023 May 1.
OBJECTIVE
Because of the anatomical complexity of the oral and maxillofacial sites, repairing bone defects in these regions is very difficult. This review article aims to consider the application of biocomposites-based strategies for dental bone regeneration.
STUDY DESIGN
Research papers related to the topic, published over the last 20 years, were selected using the Web of Science, Pubmed, Scopus, and Google Scholar databases.
RESULTS
The strategies of monophasic, biphasic/multiphasic scaffolds, and biopolymer-based nanocomposite scaffolds containing nanomaterials compared with traditional methods used for bone regeneration, such as autografts, allografts, xenografts, and alloplasts are found to be superior because of their ability to overcome the issues (e.g., limited bone sources, pain, immune responses, high cost) related to the applications of the traditional methods.
CONCLUSIONS
In addition, additive manufacturing technologies were found to be highly advantageous for improving the efficacy of biocomposite scaffolds for treating dental bone defects.
目的
由于口腔颌面部位的解剖结构复杂，修复这些区域的骨缺损非常困难。本文旨在探讨基于生物复合材料的策略在牙科骨再生中的应用。
研究设计
使用 Web of Science、Pubmed、Scopus 和 Google Scholar 数据库选择了过去 20 年与该主题相关的研究论文。
结果
与传统的骨再生方法（如自体移植物、同种异体移植物、异种移植物和同种异体移植物）相比，单相、双相/多相支架和基于生物聚合物的纳米复合材料支架等策略因其能够克服与传统方法应用相关的问题（例如，有限的骨源、疼痛、免疫反应、高成本）而被认为更优越。
结论
此外，添加剂制造技术被发现对提高生物复合材料支架治疗牙科骨缺损的疗效具有高度优势。
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