College of Light Industry Science and Engineering, Tianjin University of Science and Technology, Tianjin 300457, China.
College of Biotechnology, Tianjin University of Science and Technology, Tianjin 300222, China.
Langmuir. 2023 Sep 19;39(37):13325-13334. doi: 10.1021/acs.langmuir.3c01959. Epub 2023 Aug 23.
Titanium carbide MXene quantum dots (MQDs) possess intrinsic regulatory properties and selective toxicity to cancer cells. Here, MDQs were selected for the modification of hydroxyapatite (HA) microspheres, and MXene quantum dots-modified hydroxyapatite (MQDs-HA) hollow microspheres with controllable shapes and sizes were prepared as bone drug carriers. The results show that the prepared MQDs-HA hollow microspheres had a large BET surface area (231.2 m/g), good fluorescence, and low toxicity. In addition, MQDs-HA showed a mild storage-release behavior and good responsiveness of pH and near-infrared (NIR). Thus, the MQDs-HA hollow microspheres have broad application prospects in the field of drug delivery and photothermal therapy.
碳化钛 MXene 量子点 (MQDs) 具有内在的调节特性和对癌细胞的选择性毒性。在这里，选择 MDQs 来修饰羟基磷灰石 (HA) 微球，并制备出具有可控形状和尺寸的 MXene 量子点修饰的羟基磷灰石 (MQDs-HA) 空心微球作为骨药物载体。结果表明，所制备的 MQDs-HA 空心微球具有大的 BET 比表面积 (231.2 m/g)、良好的荧光性能和低毒性。此外，MQDs-HA 表现出温和的储存释放行为和对 pH 值和近红外 (NIR) 的良好响应性。因此，MQDs-HA 空心微球在药物输送和光热治疗领域具有广阔的应用前景。
