School of Materials Science and Engineering, Zhengzhou University, Zhengzhou 450001, China; Henan Key Laboratory of Advanced Nylon Materials and Application, Zhengzhou University, Zhengzhou 450001, China.
People's Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou 450003, China.
Int J Biol Macromol. 2023 Dec 31;253(Pt 5):127150. doi: 10.1016/j.ijbiomac.2023.127150. Epub 2023 Sep 29.
The near-infrared (NIR)/pH dual-responsive nanoplatform shows great potential in remote photothermal therapy for tumor on account of the near-infrared window in biological tissue and the mild acidic environment in tumor cells. CuS nanoplatform has become a rising star in the field of photothermal agents due to its excellent NIR responsiveness and photostability. In this work, hollow CuS nanoparticles with high photothermal conversion efficiency (42.42 %) were synthesized through a novel surfactant micelle-assisted method. Then, CuS@hydroxyapatite (HAP)/hyaluronic acid (HA) nanoclusters with controllable drug release property were prepared by capping HAP and HA on the surface of CuS via electrostatic self-assembly approach. The hollow structure of CuS and the large specific surface area of HAP ensure an outstanding doxorubicin hydrochloride (DOX) loading efficiency of 99.2 % in CuS@HAP/HA nanoclusters. The introduction of HA effectively retards the initial burst release of DOX and ensures the excellent biocompatibility of nanoclusters. More importantly, CuS@HAP/HA displays distinct NIR/pH dual-responsive drug release properties owing to the excellent NIR responsiveness of hollow CuS and the gradual dissolution of HAP under acidic conditions. This work provides an environmentally benign method to prepare CuS-based nanoclusters with excellent NIR/pH responsive drug delivery properties, which has great potential in remote photothermal therapy.
近红外（NIR）/pH 双响应纳米平台由于生物组织中的近红外窗口和肿瘤细胞中的酸性环境，在肿瘤的远程光热治疗中具有巨大的潜力。由于具有优异的近红外响应性和光稳定性，CuS 纳米平台已成为光热剂领域的一颗新星。在这项工作中，通过一种新颖的表面活性剂胶束辅助方法合成了具有高光热转换效率（42.42%）的空心 CuS 纳米粒子。然后，通过静电自组装方法在 CuS 表面包覆 HAP 和 HA，制备了具有可控药物释放性能的 CuS@羟基磷灰石（HAP）/透明质酸（HA）纳米簇。CuS 的空心结构和 HAP 的大比表面积确保了 CuS@HAP/HA 纳米簇中盐酸阿霉素（DOX）的载药效率高达 99.2%。HA 的引入有效延缓了 DOX 的初始突释，并确保了纳米簇的优异生物相容性。更重要的是，由于空心 CuS 的优异近红外响应性和 HAP 在酸性条件下的逐渐溶解，CuS@HAP/HA 表现出明显的 NIR/pH 双响应药物释放特性。这项工作提供了一种环保的方法来制备具有优异的 NIR/pH 响应药物输送性能的基于 CuS 的纳米簇，在远程光热治疗中具有巨大的潜力。
