Universidad Rey Juan Carlos, Alcorcón, España.
Universidad Rey Juan Carlos, 28922 Alcorcón, España.
Rev Neurol. 2023 Sep 1;77(5):115-124. doi: 10.33588/rn.7705.2023098.
Muscle weakness in persons with Parkinson disease (PD) has been frequently recognized as a nonspecific symptom. In other neurological conditions, lower limb weakness, specifically quadriceps weakness, is the factor that causes greater gait disability. Little research has evaluated the relationship between lower limb muscle strength, using objective tools, in PD persons and gait performance. The aim of this study was to analyze the correlation between lower limb muscle strength, using an isokinetic dynamometer, and the spatiotemporal gait parameters in PD, compared with age- and sex- matched healthy controls.
The study was conducted with 7 persons with PD -Hoehn and Yahr (HY) between II-III- and 7 healthy controls. Isokinetic knee and ankle tests at 60 and 120°/s and the 10-meter walking test at comfortable and fast walking speed, were performed on all recruited subjects.
Significant differences in lower limb strength-related measures and gait parameters were observed between persons with PD and controls. Gait parameters showed excellent correlations (rho = 0.7) for both lower limb: ankle plantar flexion work/body wearing at 180°/s with number of steps (indirect) and stride (direct) at both speeds, and between the ankle plantar flexion peak torque/ body wearing at 180°/s with number of steps (indirect) and stride (direct) at maximum speed; and between knee extension work/body wearing at 60°/s) with stride (direct) at self-selected speed.
Persons with PD (HY II-III stages) lower limb muscle strength correlates excellently with gait pattern, showing lower isokinetic strength than healthy subjects of the same age and sex. This protocol showed safety to be performed in a larger sample.
帕金森病（PD）患者的肌肉无力通常被认为是一种非特异性症状。在其他神经疾病中，下肢无力，特别是股四头肌无力，是导致更大步态障碍的因素。很少有研究评估使用客观工具评估 PD 患者下肢肌肉力量与步态表现之间的关系。本研究的目的是分析使用等速测力计评估 PD 患者下肢肌肉力量与时空步态参数之间的相关性，并与年龄和性别匹配的健康对照组进行比较。
本研究纳入了 7 名 PD-Hoehn 和 Yahr（HY）分级为 II-III 期的患者和 7 名健康对照者。对所有入组者进行了 60 和 120°/s 的等速膝关节和踝关节测试以及舒适和快速步行速度下的 10 米步行测试。
PD 患者与对照组之间在下肢力量相关指标和步态参数方面存在显著差异。步态参数在下肢之间显示出极好的相关性（rho = 0.7）：在 180°/s 时，踝关节跖屈工作/身体佩戴与步数（间接）和步幅（直接）在两种速度下，以及在 180°/s 时，踝关节跖屈峰值扭矩/身体佩戴与最大速度下的步数（间接）和步幅（直接）之间；在 60°/s 时，膝关节伸展工作/身体佩戴与自选择速度下的步幅（直接）之间。
PD（HY II-III 期）患者下肢肌肉力量与步态模式密切相关，与同年龄和性别健康受试者相比，等速力量较低。该方案显示出在更大样本中进行的安全性。
