Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Department of Research and Development, Production and Research Complex, Pasteur Institute of Iran, Tehran, Iran.
Endocr Metab Immune Disord Drug Targets. 2024;24(3):333-347. doi: 10.2174/1871530323666230823094556.
Cancer-associated fibroblasts (CAFs) as a major component of cancer stroma contribute to diverse procedures of most solid tumors and might be a targeted cancer therapy approach. Their specified features, related signaling pathways, distinct biomarkers, and sub-populations need to be deciphered. There is a need for CAF extraction or induction for in vitro investigations. Some miRNAs could activate CAF-like phenotype and they also interfere in CAF-mediated drug resistance, aggressiveness, and metastatic behaviors of several cancer cell types. Due to the complex relevance of miRNA and CAFs, these non-coding oligonucleotides may serve as attractive scope for anti-cancer targeted therapies, but the lack of an efficient delivery system is still a major hurdle. Here, we have summarized the investigated information on CAF features, isolation, and induction procedures, and highlighted the miRNA-CAF communications, providing special insight into nano-delivery systems.
癌症相关成纤维细胞（CAFs）作为肿瘤基质的主要成分，参与大多数实体瘤的多种过程，可能成为一种靶向癌症治疗方法。需要解析它们的特定特征、相关信号通路、独特的生物标志物和亚群。需要进行 CAF 提取或诱导，以便进行体外研究。一些 miRNA 可以激活 CAF 样表型，它们还干扰几种癌细胞类型中 CAF 介导的药物耐药性、侵袭性和转移行为。由于 miRNA 和 CAFs 的复杂相关性，这些非编码寡核苷酸可能成为有吸引力的抗癌靶向治疗的范围，但缺乏有效的递药系统仍然是一个主要障碍。在这里，我们总结了有关 CAF 特征、分离和诱导程序的研究信息，并强调了 miRNA-CAF 通讯，为纳米递药系统提供了特殊的见解。
