Anokute C C
J Natl Med Assoc. 1986 Aug;78(8):771-5.
A prospective epidemiologic study of spontaneous abortions and fetal wastage was undertaken over a period of 12 months in Oklahoma City. A total of 1,050 pregnant women were followed from their first prenatal visit until the termination of pregnancy. In addition to the available information in the patients' medical records, a questionnaire was administered to each patient during her first visit. Detailed information was sought on the patient's smoking and drinking habits. Alcohol and cigarettes were found to have an independent, positive association with adverse pregnancy outcome. A dose-response relationship was observed, and a synergistic effect was illustrated.
在俄克拉荷马城进行了一项为期12个月的关于自然流产和胎儿丢失的前瞻性流行病学研究。共有1050名孕妇从首次产前检查开始被跟踪随访直至妊娠结束。除了患者病历中的现有信息外，在每位患者首次就诊时还进行了问卷调查。详细询问了患者的吸烟和饮酒习惯。发现酒精和香烟与不良妊娠结局存在独立的正相关关系。观察到剂量反应关系，并说明了协同效应。
