Watkinson W P
J Toxicol Environ Health. 1986;19(2):195-206. doi: 10.1080/15287398609530920.
The effects of intravenous (iv) administration of chlordimeform (CDM) were investigated in 22- to 30-d-old pentobarbital-anesthetized Sprague-Dawley rats. Animals (n = 25) were given sequential iv injections of 5, 10, 30, 60, and 120 mg CDM/kg, or normal saline vehicle followed by a single injection of 60 mg CDM/kg. Heart rate (HR), arterial blood pressure (BP), and electrocardiogram (ECG) were monitored for all animals, while body temperature was maintained at control levels (37 degrees C). CDM produced profound acute effects on all cardiovascular parameters monitored and persistent delayed effects on HR and BP. These effects were similar to but less severe than those observed in a previous study using geriatric animals. Younger animals also appeared to be more resistant to the lethal actions of CDM.
在22至30日龄经戊巴比妥麻醉的斯普拉格-道利大鼠中研究了静脉注射杀虫脒（CDM）的效果。将动物（n = 25）依次静脉注射5、10、30、60和120 mg CDM/kg，或生理盐水载体，随后单次注射60 mg CDM/kg。监测所有动物的心率（HR）、动脉血压（BP）和心电图（ECG），同时将体温维持在对照水平（37摄氏度）。CDM对所有监测的心血管参数产生了显著的急性影响，并对HR和BP产生了持续的延迟影响。这些影响与先前使用老年动物的研究中观察到的影响相似，但程度较轻。较年轻的动物似乎对CDM的致死作用也更具抵抗力。
