Watkinson W P
J Toxicol Environ Health. 1985;15(6):729-44. doi: 10.1080/15287398509530701.
Chlordimeform (CDM), a formamidine pesticide, had a profound effect on the cardiovascular function of geriatric rats. Two-year-old pentobarbital-anesthetized Sprague-Dawley rats (n = 8) received sequential intravenous CDM injections of 5, 10, 30, and 60 mg/kg. A control group of rats (n = 8) received multiple injections of normal saline vehicle over a similar time period, followed by a single CDM injection of 60 mg/kg. Heart rate (HR), arterial blood pressure (BP), and electrocardiogram (ECG) were monitored for all animals. CDM produced abrupt decreases in HR and BP at all doses. In addition, striking changes in ECG waveforms and intervals and various conduction-related arrhythmias were observed. These acute effects triggered a reflex-mediated overshoot in HR and BP above preinjection levels, followed by a delayed, persistent depression of these parameters. Three animals from the CDM-treated group died after injection of the 30-mg/kg dose, while 60 mg/kg was lethal in the remaining animals. In the majority of cases, death appeared to be due to cardiac arrest.
杀虫脒（CDM）是一种脒类农药，对老年大鼠的心血管功能有深远影响。对8只两岁的戊巴比妥麻醉的斯普拉格-道利大鼠依次静脉注射5、10、30和60mg/kg的CDM。另一组8只大鼠作为对照组，在相似时间段内多次注射生理盐水，随后单次注射60mg/kg的CDM。监测所有动物的心率（HR）、动脉血压（BP）和心电图（ECG）。所有剂量的CDM均使HR和BP突然下降。此外，还观察到ECG波形和间期的显著变化以及各种与传导相关的心律失常。这些急性效应引发了HR和BP在注射前水平之上的反射介导的过冲，随后这些参数出现延迟的、持续的降低。CDM处理组的3只动物在注射30mg/kg剂量后死亡，而60mg/kg对其余动物是致命的。在大多数情况下，死亡似乎是由于心脏骤停。
