Marzatico F, Curti D, Dagani F, Taglietti M, Benzi G
J Neurosci Res. 1986;16(2):419-28. doi: 10.1002/jnr.490160209.
The adaptation to repeated periods of intermittent normobaric hypoxia (oxygen:nitrogen = 10:90, 12 hr daily for 5 days) of some specific enzymatic activities related to energy metabolism has been observed in different rat brain areas (cerebral cortex, hippocampus, corpus striatum, hypothalamus, cerebellum, and medulla oblongata). The evaluation of the maximum rate (Vmax) of the enzymes was carried out on: the homogenate "in toto," the nonsynaptic mitochondrial fraction, and the crude synaptosomal fraction. The adaptation to intermittent normobaric hypoxic exposure was characterized by significant modifications of some enzyme activities in the homogenate "in toto" (decrease of hexokinase activity in cerebellum), in the nonsynaptic mitochondrial fraction (increase of succinate dehydrogenase activity in corpus striatum and decrease of cytochrome oxidase activity in cerebral cortex), and, particularly, in the synaptosomal fraction (decrease of cytochrome oxidase activity in cerebral cortex, hippocampus, corpus striatum, and cerebellum, and decrease of malate dehydrogenase and lactate dehydrogenase activity in cerebellum). The adaptation to normobaric intermittent hypoxia differs according to the brain area, subcellular fraction, and enzyme activity tested.
在不同大鼠脑区（大脑皮层、海马体、纹状体、下丘脑、小脑和延髓）中，已观察到与能量代谢相关的某些特定酶活性对间歇性常压低氧反复暴露（氧气：氮气 = 10:90，每天12小时，共5天）的适应性变化。对酶的最大反应速度（Vmax）的评估是在以下样本上进行的：全脑组织匀浆、非突触线粒体组分以及粗制突触体组分。对间歇性常压低氧暴露的适应性表现为全脑组织匀浆（小脑己糖激酶活性降低）、非突触线粒体组分（纹状体琥珀酸脱氢酶活性增加，大脑皮层细胞色素氧化酶活性降低），尤其是突触体组分（大脑皮层、海马体、纹状体和小脑的细胞色素氧化酶活性降低，小脑苹果酸脱氢酶和乳酸脱氢酶活性降低）中某些酶活性的显著改变。对常压低氧间歇性暴露的适应性因脑区、亚细胞组分和所测试的酶活性不同而有所差异。
