Pan Wei-Gang, Hu Xiao-Yue, Zhu Dan-di, Li Li, Bao Feng, Ren Li, Mao Pei-Xian, Ma Xin, Ren Yan-Ping, Tang Yi-Lang
Beijing Key Laboratory of Mental Disorders, National Clinical Research Center for Mental Disorders & National Center for Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing, China.
Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China.
Front Psychiatry. 2023 Aug 8;14:1240261. doi: 10.3389/fpsyt.2023.1240261. eCollection 2023.
Cognitive impairment is common and linked to poor outcomes in patients with late-onset depression (LOD). The cognitive effects of repetitive transcranial magnetic stimulation (rTMS) for LOD are not well understood. This study aimed to investigate the effects of rTMS on cognitive function in elderly patients with LOD.
In total, 58 elderly patients (aged 60 to 75 years) with depression were enrolled and randomly assigned to an active rTMS group or a sham group. The participants received active or sham rTMS over the left dorsolateral prefrontal cortex for 4 weeks, 5 days a week, at a frequency of 10 Hz rTMS and 120% of the motor threshold (MT). Cognitive function was assessed using the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) at baseline, the end of the 4 week treatment period, and at the 4 week follow-up.
The active rTMS group showed significant improvements in immediate memory and attention scores on the RBANS compared to the sham group. However, no significant differences were observed between the two groups in other cognitive domains assessed by the RBANS. No serious adverse events related to rTMS treatment were observed.
Treatment with 120% MT rTMS was associated with improvement in cognitive defects related to the active phase of LOD. These findings suggest that rTMS could provide early improvements in cognitive function in clinical settings for elderly patients with LOD.: https://www.chictr.org.cn/showproj.html?proj=40698, identifier ChiCTR1900024445.
认知障碍在晚发性抑郁症（LOD）患者中很常见，且与不良预后相关。重复经颅磁刺激（rTMS）对LOD的认知影响尚不清楚。本研究旨在探讨rTMS对老年LOD患者认知功能的影响。
总共招募了58名年龄在60至75岁之间的抑郁症老年患者，并将他们随机分为rTMS治疗组或假刺激组。参与者在左侧背外侧前额叶皮质接受主动或假rTMS治疗，为期4周，每周5天，频率为10Hz的rTMS，强度为运动阈值（MT）的120%。在基线、4周治疗期结束时以及4周随访时，使用可重复神经心理状态评估量表（RBANS）评估认知功能。
与假刺激组相比，rTMS治疗组在RBANS的即时记忆和注意力得分上有显著改善。然而，在RBANS评估的其他认知领域，两组之间未观察到显著差异。未观察到与rTMS治疗相关的严重不良事件。
120%MT的rTMS治疗与改善LOD急性期相关的认知缺陷有关。这些发现表明，rTMS可以在临床环境中为老年LOD患者的认知功能提供早期改善。：https://www.chictr.org.cn/showproj.html?proj=40698，标识符ChiCTR1900024445 。
