Tateishi Hiroshi, Mizoguchi Yoshito, Monji Akira
Department of Psychiatry, Faculty of Medicine, Saga University, Saga, Japan.
Front Psychiatry. 2022 Feb 24;13:834425. doi: 10.3389/fpsyt.2022.834425. eCollection 2022.
The lifetime prevalence of depression is reported to be >10%, and it is an important illness that causes various disabilities over a long period of life. Neuroinflammation process is often reported to be closely linked to the pathophysiology of depression. Approximately one-third of depression is known to be treatment-resistant depression (TRD), in which the symptoms are refractory to adequate treatment. Cognitive dysfunction is one of the most important symptoms of depression that impedes the rehabilitation of patients with depression. Repetitive transcranial magnetic stimulation (rTMS) is a minimally invasive and effective treatment for TRD and is also known to be effective in cognitive dysfunction in depression. Since the details of the therapeutic mechanism of rTMS are still unknown, we have been conducting studies to clarify the therapeutic mechanism of rTMS, especially focusing on cognitive dysfunction in depression. In the present review, we present our latest results and discuss them from the standpoint of the neuroinflammation hypothesis of depression, while citing relevant literature.
据报道，抑郁症的终生患病率>10%，它是一种重要疾病，会在很长一段生命历程中导致各种残疾。神经炎症过程常被报道与抑郁症的病理生理学密切相关。已知约三分之一的抑郁症为难治性抑郁症（TRD），其症状对充分治疗无反应。认知功能障碍是抑郁症最重要的症状之一，会阻碍抑郁症患者的康复。重复经颅磁刺激（rTMS）是一种治疗TRD的微创且有效方法，也已知对抑郁症的认知功能障碍有效。由于rTMS治疗机制的细节仍不清楚，我们一直在进行研究以阐明rTMS的治疗机制，尤其关注抑郁症中的认知功能障碍。在本综述中，我们展示最新结果，并在引用相关文献的同时，从抑郁症的神经炎症假说角度进行讨论。
