Uvelius B
J Urol. 1986 Oct;136(4):949-52. doi: 10.1016/s0022-5347(17)45138-x.
Following five weeks of alloxan-induced diabetes, female rats were killed and the urinary bladder was used either for organ bath experiments, collagen determination or electron microscopy. Mean bladder weight increased from 70 +/- 3 (SE, n = 8) for controls to 131 +/- 7 mg. (n = 9) for the diabetic rats. Collagen concentration decreased from 104 +/- 5 (n = 8) to 69 +/- 4 (n = 9) micrograms/mg. but due to the weight gain total bladder collagen increased from 7.4 +/- 0.6 to 8.9 +/- 0.3 mg. Electron microscopy indicated an increase in mean cross-sectional area of the detrusor smooth muscle cells from 8.1 +/- 0.5 (n = 132) to 19 +/- 0.9 (n = 144) mu 2. Despite these changes the bladders from diabetic animals and the controls had similar characteristics with regard to nerve mediated frequency-response relations, atropine resistance, responses to alpha-agonists and high-K+ solution. No functional neurogenic lesion and no impairment of smooth muscle cell contractility could thus be detected, and it is proposed that the bladder hypertrophy in the diabetic animals is due to a physiological adaptation to the four-fold increase in urinary production.
在给予四氧嘧啶诱导糖尿病五周后，处死雌性大鼠，取其膀胱用于器官浴实验、胶原蛋白测定或电子显微镜检查。对照组大鼠膀胱平均重量为70±3（标准误，n = 8）毫克，糖尿病大鼠膀胱平均重量为131±7毫克（n = 9）。胶原蛋白浓度从104±5（n = 8）微克/毫克降至69±4（n = 9）微克/毫克，但由于重量增加，膀胱总胶原蛋白量从7.4±0.6毫克增加至8.9±0.3毫克。电子显微镜检查显示，逼尿肌平滑肌细胞平均横截面积从8.1±0.5（n = 132）μm²增加至19±0.9（n = 144）μm²。尽管有这些变化，但糖尿病动物和对照组的膀胱在神经介导的频率-反应关系、阿托品耐受性、对α-激动剂和高钾溶液的反应方面具有相似的特征。因此，未检测到功能性神经源性病变和平滑肌细胞收缩力受损，据推测糖尿病动物膀胱肥大是对尿量增加四倍的生理适应。
