Vora Niraj, Kalagiri Ram R, Shetty Kushi, Mustafa Yara, Kundysek Waverly, Raju Muppala, Govande Vinayak, Beeram Madhava, Uddin Mohammad Nasir
Department of Pediatrics and Neonatology, Baylor Scott & White Medical Center - Temple, Temple, Texas, USA.
McNeil High School, Austin, Texas, USA.
Proc (Bayl Univ Med Cent). 2023 Jun 22;36(5):572-577. doi: 10.1080/08998280.2023.2223449. eCollection 2023.
Preeclampsia (PreE), the de novo onset of hypertension and proteinuria at 20 weeks of gestation, is a leading cause of maternal and fetal morbidity and mortality. This study compared inflammatory biomarkers in PreE and normal pregnancies using paired samples of mothers and neonates.
Twenty normal pregnant and 27 PreE patients were monitored for biomarkers, neonatal outcomes, and placental morphologies. Fetal and maternal serum levels of vascular endothelial growth factor (VEGF), placental growth factor (PlGF), soluble endoglin (sENG), and soluble fms-like tyrosine kinase-1 (sFLT-1) were measured by enzyme-linked immunosorbent assay.
Placental thickness was 25 mm in early PreE subjects compared to 32 mm in late PreE subjects ( < 0.05). Placental volume was 296 cm in early PreE compared to 393 cm in late PreE ( < 0.05). The average hospital stay for PreE babies was longer (20 ± 5 days) compared to babies from normal pregnancies (2 ± 1 days; < 0.05). PreE babies had a lower Ponderal index (2.28 ± 0.3) than those from normal pregnancies (2.95 ± 0.2; < 0.05). sENG and sFLT-1 had cord values like the maternal values, while VEGF and PlGF did not.
PreE alters the intrauterine environment by activating chemical mediators that result in maternal and fetal complications.
子痫前期（PreE）是指妊娠20周时新发高血压和蛋白尿，是孕产妇和胎儿发病及死亡的主要原因。本研究使用母亲和新生儿的配对样本比较了子痫前期和正常妊娠中的炎症生物标志物。
对20名正常孕妇和27名子痫前期患者进行生物标志物、新生儿结局和胎盘形态监测。通过酶联免疫吸附测定法测量胎儿和母亲血清中的血管内皮生长因子（VEGF）、胎盘生长因子（PlGF）、可溶性内皮糖蛋白（sENG）和可溶性fms样酪氨酸激酶-1（sFLT-1）水平。
早期子痫前期患者的胎盘厚度为25毫米，而晚期子痫前期患者为32毫米（P<0.05）。早期子痫前期患者的胎盘体积为296立方厘米，晚期子痫前期患者为393立方厘米（P<0.05）。子痫前期婴儿的平均住院时间更长（20±5天），而正常妊娠婴儿的住院时间为（2±1天；P<0.05）。子痫前期婴儿的体重指数（2.28±0.3）低于正常妊娠婴儿（2.95±0.2；P<0.05）。sENG和sFLT-1的脐带值与母亲的值相似，而VEGF和PlGF则不同。
子痫前期通过激活化学介质改变子宫内环境，从而导致母婴并发症。
