Malshe Amol K, Sibai Baha M
Department of Obstetrics, Gynecology and Reproductive Sciences, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, Texas.
Clin Obstet Gynecol. 2017 Mar;60(1):134-140. doi: 10.1097/GRF.0000000000000267.
Preeclampsia is a pregnancy-specific hypertensive disorder with multisystem involvement and is a significant cause of obstetric morbidity and mortality worldwide. A major issue in the treatment of preeclampsia stems from its still significant rates of misclassification and misdiagnosis. Angiogenic factors have been speculated as a possible diagnostic modality due to a perceived imbalance in angiogenesis in preeclampsia. Factors currently studied include soluble fms-like protein kinase 1 and placental growth factor. Because of significant mortality associated with preeclampsia it is felt that both early and accurate diagnosis of preeclampsia is imperative if this disease process is to be treated.
子痫前期是一种妊娠期特有的多系统受累的高血压疾病，是全球范围内产科发病和死亡的重要原因。子痫前期治疗中的一个主要问题源于其误诊和漏诊率仍然很高。由于子痫前期血管生成存在明显失衡，血管生成因子被推测为一种可能的诊断方式。目前研究的因子包括可溶性fms样蛋白激酶1和胎盘生长因子。由于子痫前期会导致显著的死亡率，因此人们认为，如果要治疗这种疾病，早期准确诊断子痫前期至关重要。
