Goto Hiroyasu, Kinoshita Manabu, Oshima Naoki
Department of Nephrology and Endocrinology, National Defense Medical College, Tokorozawa, Japan.
Department of Immunology and Microbiology, National Defense Medical College, Tokorozawa, Japan.
Front Med (Lausanne). 2023 Aug 8;10:1250457. doi: 10.3389/fmed.2023.1250457. eCollection 2023.
Heatstroke can cause multiple organ failure and systemic inflammatory response syndrome as the body temperature rises beyond the body's ability to regulate temperature in a hot environment. Previous studies have indicated that heatstroke-induced acute kidney injury (AKI) can lead to chronic kidney disease. Therefore, there is an urgent need to elucidate the mechanism of heatstroke-induced AKI and to establish methods for its prevention and treatment. Recent reports have revealed that innate immunity, including neutrophils, macrophages, lymphocytes, and mast cells, is deeply involved in heat-induced AKI. In this review, we will discuss the roles of each immune cell in heat-induced renal injury and their potential therapeutic use.
在炎热环境中，当体温升高超过身体调节温度的能力时，中暑可导致多器官功能衰竭和全身炎症反应综合征。先前的研究表明，中暑诱导的急性肾损伤（AKI）可导致慢性肾病。因此，迫切需要阐明中暑诱导AKI的机制，并建立其预防和治疗方法。最近的报道显示，包括中性粒细胞、巨噬细胞、淋巴细胞和肥大细胞在内的先天免疫与热诱导的AKI密切相关。在这篇综述中，我们将讨论每种免疫细胞在热诱导肾损伤中的作用及其潜在的治疗用途。
