Department of Radiology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
J Ultrasound Med. 2023 Dec;42(12):2749-2756. doi: 10.1002/jum.16309. Epub 2023 Aug 24.
To characterize the technical performance of a multisample ultrasound point shear wave elastography (pSWE) technique that allows 15 individual measurements of liver stiffness in a single acquisition.
In 56 overweight and obese adults, research ultrasound examinations were performed using conventional pSWE and multisample pSWE (Sequoia; Siemens Healthineers). Five independent measurements were acquired with the conventional technique over five consecutive breath holds (5C1 and DAX transducers). A single multisample acquisition (DAX transducer) of up to 15 unique measurements was acquired during a single breath hold. All imaging was performed before (baseline) and after a "coffee break" (repeat). Median liver stiffness measurements between techniques and between baseline and repeat imaging were compared using Pearson correlation (r) and intra-class correlation (ICC) coefficients.
Mean participant age was 33.7 ± 11.4 years; 40 participants were female. There was high correlation between conventional pSWE measurements obtained using the 5C1 and DAX transducers at baseline (r = .75 [95% CI: 0.61-0.85], P < .0001) and repeat (r = .88 [95% CI: 0.78-0.92], P < .0001). There was moderate agreement between conventional pSWE measurements obtained using the 5C1 and DAX transducers at baseline (ICC = 0.69 [95% CI: 0.52-0.81]), and good agreement at repeat (ICC = 0.81 [95% CI: 0.65-0.90]). There was moderate correlation (r = .59 [95% CI: 0.39-0.74], P < .0001) and moderate agreement (ICC = 0.58 [95% CI: 0.38-0.73]) between baseline conventional and multisample pSWE measurements acquired using the DAX transducer; there was high correlation (r = .73 [95% CI: 0.57-0.83], P < .0001) and moderate agreement (ICC = 0.72 [95% CI: 0.56-0.82] between techniques at repeat. There was moderate correlation (r = .65 [95% CI: 0.46-0.78], P < .0001) and moderate agreement (ICC = 0.64 [95% CI: 0.45-0.77]) between baseline and repeat multisample pSWE measurements.
Multisample pSWE, allowing up to 15 measurements in a single breath hold, showed moderate to high correlation and moderate agreement with conventional pSWE.
描述一种新的多样本超声点剪切波弹性成像（pSWE）技术的技术性能，该技术可在单次采集时对肝脏硬度进行 15 次独立测量。
在 56 名超重和肥胖成年人中，使用常规 pSWE 和多样本 pSWE（Sequoia；西门子医疗）进行研究性超声检查。常规技术在 5 次连续呼吸暂停（5C1 和 DAX 探头）中采集 5 次独立测量。在单次呼吸暂停期间，可使用单个 DAX 探头采集多达 15 个独特的测量值。所有成像均在（基线）和（重复）咖啡休息后进行。使用 Pearson 相关系数（r）和组内相关系数（ICC）比较两种技术以及基线和重复成像之间的中位肝脏硬度测量值。
平均参与者年龄为 33.7±11.4 岁；40 名参与者为女性。基线时，使用 5C1 和 DAX 探头获得的常规 pSWE 测量值之间具有高度相关性（r=0.75[95%CI：0.61-0.85]，P<0.0001）和重复（r=0.88[95%CI：0.78-0.92]，P<0.0001）。基线时，使用 5C1 和 DAX 探头获得的常规 pSWE 测量值之间具有中度一致性（ICC=0.69[95%CI：0.52-0.81]），重复时具有良好一致性（ICC=0.81[95%CI：0.65-0.90]）。基线时，使用 DAX 探头获得的常规和多样本 pSWE 测量值之间具有中度相关性（r=0.59[95%CI：0.39-0.74]，P<0.0001）和中度一致性（ICC=0.58[95%CI：0.38-0.73]）；重复时，两种技术之间具有高度相关性（r=0.73[95%CI：0.57-0.83]，P<0.0001）和中度一致性（ICC=0.72[95%CI：0.56-0.82]）。基线和重复时，多样本 pSWE 测量值之间具有中度相关性（r=0.65[95%CI：0.46-0.78]，P<0.0001）和中度一致性（ICC=0.64[95%CI：0.45-0.77]）。
允许在单次呼吸暂停中进行多达 15 次测量的多样本 pSWE 与常规 pSWE 具有中度至高度相关性和中度一致性。
