Rocky Vista University, Ivins, UT, USA.
Rocky Vista University, Ivins, UT, USA.
Clin Imaging. 2021 Dec;80:424-429. doi: 10.1016/j.clinimag.2021.08.025. Epub 2021 Sep 17.
The aim of the study was to test the reproducibility of performing conventional point shear wave elastography (pSWE), auto-pSWE, and ultrasound derived fat fraction (UDFF) in adult livers.
The Institutional Review Board approved the study and all participants provided written informed consent. Conventional pSWE (obtaining 10 measurements through 10 acquisitions), auto-pSWE (automatically obtaining 15 measurements by a single acquisition), and UDFF (one measurement obtained by one acquisition) of the liver were prospectively performed in 21 participants (10 men, 11 women, mean age 63y) by senior and junior operators in February-May 2021. Shear wave velocity (SWV, m/s) of the liver was measured by conventional pSWE and auto-pSWE. Intraclass correlation coefficient (ICC) and Bland-Altman limits of agreement were used to test intra-observer repeatability and inter-observer reproducibility in measuring pSWE, auto-pSWE, and UDFF.
ICC for testing intra-observer repeatability and inter-observer reproducibility in performing pSWE, auto-pSWE, and UDFF was >0.85 (95% confidence interval 0.85-0.99). The mean difference of 95% Bland-Altman limits of agreement was -0.02 (upper 0.09, lower -0.12) and the correlation of SWV measured between conventional pSWE and auto-pSWE methods was strong (r = 0.87).
Our results suggest good repeatability and reproducibility in measuring UDFF and SWV in adult livers. The auto-pSWE has higher reliability, reproducibility and time efficacy in measuring SWV of adult livers when compared to conventional pSWE method.
本研究旨在测试成人肝脏常规点剪切波弹性成像（pSWE）、自动 pSWE 和超声衍生脂肪分数（UDFF）的可重复性。
机构审查委员会批准了这项研究，所有参与者均提供了书面知情同意书。2021 年 2 月至 5 月，由高级和初级操作人员对 21 名参与者（10 名男性，11 名女性，平均年龄 63 岁）进行了前瞻性的常规 pSWE（通过 10 次采集获得 10 次测量）、自动 pSWE（通过单次采集自动获得 15 次测量）和 UDFF（单次采集获得 1 次测量）。肝脏的剪切波速度（SWV，m/s）通过常规 pSWE 和自动 pSWE 进行测量。使用组内相关系数（ICC）和 Bland-Altman 协议界限来测试测量 pSWE、自动 pSWE 和 UDFF 时的观察者内重复性和观察者间可重复性。
测试观察者内重复性和观察者间可重复性时，pSWE、自动 pSWE 和 UDFF 的 ICC 均>0.85（95%置信区间 0.85-0.99）。95% Bland-Altman 协议界限的平均差值为-0.02（上限 0.09，下限-0.12），常规 pSWE 和自动 pSWE 方法测量的 SWV 之间具有较强的相关性（r=0.87）。
我们的结果表明，在测量成人肝脏的 UDFF 和 SWV 时，具有良好的重复性和可再现性。与常规 pSWE 方法相比，自动 pSWE 方法在测量成人肝脏的 SWV 时具有更高的可靠性、可重复性和时间效率。
