氟[¹⁸F]氟代脱氧葡萄糖 PET/CT 作为去势抵抗性前列腺腺癌患者骨转移诊断工具的初步研究及血和骨分子检测的相关性分析（FACT 研究）。
A Pilot Study of F-18 Fluciclovine-PET/CT as a Diagnostic Tool for Bone Metastases in Patients With Castrate Resistant Prostate Adenocarcinoma and Correlative Analysis of Blood and Bone Molecular Testing (The FACT Study).
机构信息
Department of Medicine, Division of Hematology-Oncology, Mayo Clinic Cancer Center, Mayo Clinic Florida, Jacksonville, FL, USA.
Department of Medical Imaging, University of Arizona, Tucson, AZ, USA.
出版信息
Oncologist. 2023 Nov 2;28(11):e1114-e1117. doi: 10.1093/oncolo/oyad242.
BACKGROUND
Suspicious F-18 fluciclovine PET/CT findings for osseous metastases from prostate cancer (PC) were targeted for core needle biopsy. We correlated the maximum standardized uptake value (SUVmax) of biopsied lesions, with biopsy results, other diagnostic outcomes, and blood and tissue molecular analysis (TMA).
MATERIAL AND METHODS
Patients with castrate resistant prostate cancer (CRPC) were recruited from a university oncology clinic. SUVmax, histology, blood, and TMA were correlated.
RESULTS
Fifteen patients were enrolled and 12 underwent bone biopsies. Fifty percent of bone biopsies demonstrated malignancy. Higher SUVmax was associated with positive biopsies for adenocarcinoma (P = .003), and lesions with SUVmax ≥ 5.1 were all positive for malignancy. Significant correlation between blood and somatic TMA (P = .002) was also found.
CONCLUSION
Higher uptake of F-18 fluciclovine was associated with higher predictive value for osseous metastasis on biopsy. There was a significant correlation between blood and TMA.
背景
针对前列腺癌（PC）骨转移的 F-18 氟柳氯比昔 PET/CT 可疑表现进行了核心针活检。我们将活检病变的最大标准化摄取值（SUVmax）与活检结果、其他诊断结果以及血液和组织分子分析（TMA）进行了相关性分析。
材料与方法
从一所大学肿瘤诊所招募了去势抵抗性前列腺癌（CRPC）患者。对 SUVmax、组织学、血液和 TMA 进行了相关性分析。
结果
共纳入 15 例患者，其中 12 例行骨活检。50%的骨活检显示为恶性肿瘤。SUVmax 越高，腺癌阳性活检的相关性越高（P=0.003），SUVmax≥5.1 的病变均为恶性肿瘤阳性。还发现血液和体细胞 TMA 之间存在显著相关性（P=0.002）。
结论
F-18 氟柳氯比昔摄取量较高与骨转移活检的预测值较高相关。血液和 TMA 之间存在显著相关性。
Zotero 插件