Department of Entomology, University of Kentucky, Lexington, KY, USA.
Department of Entomology, Plant Pathology and Weed Science, New Mexico State University, Las Cruces, NM, USA.
J Med Entomol. 2023 Nov 14;60(6):1269-1277. doi: 10.1093/jme/tjad103.
Histamine is a biogenic amine that regulates multiple physiological functions in diverse organisms, specifically playing a central role in the mammalian immune response. The common bed bug, Cimex lectularius L. (Hemiptera: Cimicidae), excretes histamine in large amounts in its feces as a component of its aggregation pheromone, which contaminates homes. The potential health risks associated with the presence of indoor histamine are unclear, but to predict future exposure risks, it is critical that we understand if other arthropods excrete histamine in any discernible phylogenetic pattern. In the present study, we evaluated histamine excretion by various arthropods; specifically those commonly found in large numbers indoors, other hematophagous species, and other species in the order Hemiptera. To evaluate arthropods for histamine excretion, rearing containers for each arthropod were swabbed and/or the harborage substrates were collected. Samples were then analyzed for the presence of histamine using gas chromatography-mass spectrometry. For those arthropods where histamine was present above the method detection limit, total histamine excretion was quantified over a period of 2 wk. Our results indicate that histamine excretion is limited to hematophagous hemipterans (bed bugs, bat bugs, tropical bed bugs, and kissing bugs), suggesting that indoor histamine contamination in the United States can be primarily linked to bed bugs.
组胺是一种生物胺，调节多种生理功能的生物，特别是在哺乳动物的免疫反应中起着核心作用。常见的臭虫，Cimex lectularius L.（半翅目：Cimicidae），大量排泄组胺在其粪便中的一个组成部分它的聚集信息素，污染家庭。与室内组胺存在相关的潜在健康风险尚不清楚，但为了预测未来的暴露风险，了解其他节肢动物是否以任何可识别的系统发育模式排泄组胺是至关重要的。在本研究中，我们评估了各种节肢动物的组胺排泄；特别是那些在室内大量发现的，其他吸血物种，以及其他半翅目物种。为了评估节肢动物的组胺排泄，用拭子擦拭每个节肢动物的饲养容器，或收集栖息基质。然后使用气相色谱-质谱法分析样品中是否存在组胺。对于那些组胺含量超过方法检测限的节肢动物，在 2 周的时间内定量测定总组胺排泄量。我们的结果表明，组胺排泄仅限于吸血半翅目（臭虫、蝙蝠臭虫、热带臭虫和接吻臭虫），这表明美国室内组胺污染主要与臭虫有关。
