米力农、哇巴因和钙对病变人类心室肌的相加正性肌力作用。

Additive positive inotropic effects of milrinone, ouabain and calcium in diseased human ventricular myocardium.

作者信息

Brown L, Näbauer M, Erdmann E

出版信息

Klin Wochenschr. 1986 Aug 1;64(15):708-12. doi: 10.1007/BF01712056.

DOI:10.1007/BF01712056

PMID:3762018

Abstract

The interactions of milrinone, ouabain and calcium on force of contraction in isolated, contracting human papillary muscle strips were measured. Milrinone (EC50, 8 X 10(-5)M) increased force of contraction maximally by 2.8 +/- 0.8 mN at 5 X 10(-4)M; significantly less than either ouabain (1 X 10(-7)M; 4.8 +/- 0.5 mN increase) or calcium (15 mM; 6.2 +/- 0.6 mN increase). A submaximal, but not a maximal, inotropic effect of ouabain could be increased by the addition of milrinone; in contrast, both ouabain and calcium increased the maximal inotropic effect of milrinone by 1.7 +/- 0.2 mN and 2.7 +/- 0.3 mN, respectively. The combined inotropic effect of milrinone with either ouabain of 4.2 +/- 0.3 mN or calcium of 5.6 +/- 0.4 mN was not different from that with calcium or ouabain alone. We conclude that further positive inotropic effects should be expected when digitalis is given to patients with congestive heart failure who are already optimally treated with milrinone.

摘要

测定了米力农、哇巴因和钙对离体收缩的人乳头肌条收缩力的相互作用。米力农（EC50，8×10⁻⁵M）在5×10⁻⁴M时使收缩力最大增加2.8±0.8mN；明显小于哇巴因（1×10⁻⁷M；增加4.8±0.5mN）或钙（15mM；增加6.2±0.6mN）。添加米力农可增强哇巴因的次最大但非最大的正性肌力作用；相反，哇巴因和钙分别使米力农的最大正性肌力作用增加1.7±0.2mN和2.7±0.3mN。米力农与哇巴因（4.2±0.3mN）或钙（5.6±0.4mN）联合的正性肌力作用与单独使用钙或哇巴因时无差异。我们得出结论，对于已经用米力农进行最佳治疗的充血性心力衰竭患者，给予洋地黄时应预期会有进一步的正性肌力作用。