Liu Yuxin, Zhu Zhengming, Jiang Ling
College of Food Science and Light Industry, Nanjing Tech University, Nanjing 211816, China.
College of Food Science and Light Industry, Nanjing Tech University, Nanjing 211816, China.
Trends Microbiol. 2023 Nov;31(11):1099-1101. doi: 10.1016/j.tim.2023.08.001. Epub 2023 Aug 23.
Probiotics can be programmed to sense and respond to intracellular disease signals to deliver the desired therapeutic effectors. The sense-and-respond genetic circuits, especially self-tunable ones, hold promise in improving the precision, effectiveness, and intelligence of therapeutic activities. Here, we present notable advances in the creation of engineered probiotics that harbour sense-and-respond genetic circuits.
益生菌可以被设计成能够感知并响应细胞内疾病信号，从而递送所需的治疗效应物。这种感知与响应的遗传回路，尤其是可自我调节的遗传回路，有望提高治疗活动的精准度、有效性和智能性。在此，我们展示了在构建含有感知与响应遗传回路的工程益生菌方面取得的显著进展。
