Guo Huijuan
Communications Chemistry, .
Commun Chem. 2023 Aug 24;6(1):178. doi: 10.1038/s42004-023-00987-2.
Fluorochemicals have a wide range of applications in industry, but accessing these relies on the energy intensive conversion of acid-grade fluorspar (CaF) to toxic hydrogen fluoride (HF) gas, which is in turn used for the downstream production of fluorochemicals via multistep processes. Now, directly treating acid-grade fluorspar with dipotassium hydrogen phosphate (KHPO) under mechanochemical conditions affords a fluorinating reagent for direct S–F and C(sp/sp)–F bond construction, bypassing the need for HF production.
含氟化合物在工业上有广泛应用，但获取这些化合物依赖于将酸级萤石（CaF）能源密集型转化为有毒的氟化氢（HF）气体，而氟化氢气体又通过多步工艺用于含氟化合物的下游生产。现在，在机械化学条件下用磷酸氢二钾（KHPO）直接处理酸级萤石可得到一种用于直接构建S-F和C(sp/sp)-F键的氟化试剂，无需生产HF。
