• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

职业性亚慢性接触萤石导致的眼表和呼吸道损伤:病例报告及其他考量

Ocular surface and respiratory tract damages from occupational, sub-chronic exposure to fluorspar: case report and other considerations.

作者信息

Napoli Pietro Emanuele, Nioi Matteo, Iovino Claudio, Sanna Raffaele, d'Aloja Ernesto, Fossarello Maurizio

机构信息

Department of Surgical Sciences, Eye Clinic, University of Cagliari, Cagliari, Italy.

Department of Public Health, Clinical and Molecular Medicine, Forensic Science Unit, University of Cagliari, Cagliari, Italy.

出版信息

Int Ophthalmol. 2019 May;39(5):1175-1178. doi: 10.1007/s10792-018-0915-1. Epub 2018 Mar 28.

DOI:10.1007/s10792-018-0915-1
PMID:29594792
Abstract

OBJECTIVES

To report the ocular surface and respiratory tract damages due to a sub-chronic (3 months), occupational exposure to fluorspar dust in case of inconsistent use of personal protective equipment.

METHODS

A 50-year-old man was referred to our clinic with bilateral conjunctival injection, ocular foreign body sensation and symptoms of ocular discomfort. He reported having 3 days before an urgent hospital admission for dyspnoea with odynophagia, hyposmia, nausea, vomiting, headache and asthenia. Otorhinolaryngological examination revealed a severe hypertrophic rhinopharyngitis and a significant decrease in overall sensitivity to olfactory stimuli. General anamnesis was negative for previous diseases or medication use.

RESULTS

Ocular examination revealed a diffuse injection of the ocular surface with some areas of conjunctival and limbal ischaemia, a best-corrected visual acuity of 20/25 in both eyes, an intraocular pressure of 23 and 21 mmHg, respectively, in the right and in the left eyes, and a normal fundus oculi. Assessment of the tear film and ocular surface showed the presence of dry eye disease. Based on medical history and clinical tests, initial diagnostic hypothesis was ocular surface burn due to chemical exposure, i.e. to fluorspar. Therefore, anterior segment fluorescein angiography was performed to confirm the extension of conjunctival and limbal ischaemia. Thus, ocular ischaemia was detected in approximately 10 clock hours of limbus and in 50% of conjunctiva.

CONCLUSIONS

The present work remarks the importance of using protective equipment for preventing ocular and respiratory tract damages in workers occupationally exposed to the 'acid-grade fluorite'.

摘要

目的

报告在个人防护设备使用不一致的情况下,因职业性长期(3个月)接触萤石粉尘导致的眼表和呼吸道损伤。

方法

一名50岁男性因双眼结膜充血、眼部异物感及眼部不适症状被转诊至我院。他报告称,在因呼吸困难、吞咽痛、嗅觉减退、恶心、呕吐、头痛和乏力紧急入院前3天出现上述症状。耳鼻喉科检查显示严重的肥厚性鼻咽炎,对嗅觉刺激的总体敏感性显著降低。既往病史和用药史均无异常。

结果

眼部检查发现眼表弥漫性充血,结膜和角膜缘部分区域缺血,双眼最佳矫正视力均为20/25,右眼眼压为23 mmHg,左眼眼压为21 mmHg,眼底正常。泪膜和眼表评估显示存在干眼症。根据病史和临床检查,初步诊断假设为化学物质暴露(即萤石)导致的眼表烧伤。因此,进行了眼前段荧光素血管造影以确认结膜和角膜缘缺血的范围。结果发现,角膜缘约10个钟点区域及50%的结膜存在眼部缺血。

结论

本研究强调了使用防护设备对预防职业接触“酸级萤石”的工人眼呼吸道损伤的重要性。

相似文献

1
Ocular surface and respiratory tract damages from occupational, sub-chronic exposure to fluorspar: case report and other considerations.职业性亚慢性接触萤石导致的眼表和呼吸道损伤:病例报告及其他考量
Int Ophthalmol. 2019 May;39(5):1175-1178. doi: 10.1007/s10792-018-0915-1. Epub 2018 Mar 28.
2
Ocular manifestations in patient with congenital erythropoietic porphyria.先天性红细胞生成性卟啉病患者的眼部表现。
Indian J Ophthalmol. 2019 Oct;67(10):1765-1768. doi: 10.4103/ijo.IJO_1776_18.
3
Ocular cystinosis: Rarity redefined.眼胱氨酸病:重新定义的罕见病。
Indian J Ophthalmol. 2019 Jul;67(7):1158-1159. doi: 10.4103/ijo.IJO_1467_18.
4
Multistep Grading System for Evaluation of Chronic Ocular Sequelae in Patients With Stevens-Johnson Syndrome.多步骤分级系统评估史蒂文斯-约翰逊综合征患者的慢性眼部后遗症。
Am J Ophthalmol. 2019 Jul;203:69-77. doi: 10.1016/j.ajo.2019.01.028. Epub 2019 Feb 4.
5
The relation of conjunctival and corneal findings in severe ocular allergies.严重眼部过敏中结膜和角膜表现的关系
Cornea. 2004 Jul;23(5):464-7. doi: 10.1097/01.ico.0000114836.13127.45.
6
In Vivo Confocal Microscopy of Prominent Conjunctival and Corneal Nerves in Multiple Endocrine Neoplasia Type 2B.2B 型多发性内分泌肿瘤中明显的结膜和角膜神经的体内共聚焦显微镜检查。
Cornea. 2019 Nov;38(11):1453-1455. doi: 10.1097/ICO.0000000000002028.
7
Effects of a 0.9% sodium chloride ophthalmic solution on the ocular surface of symptomatic contact lens wearers.0.9%氯化钠滴眼液对有症状的隐形眼镜佩戴者眼表的影响。
Can J Ophthalmol. 2005 Feb;40(1):45-50. doi: 10.1016/S0008-4182(05)80116-4.
8
Daily versus monthly disposable contact lens: Which is better for ocular surface physiology and comfort?日抛型与月抛型隐形眼镜:哪一种对眼表面生理和舒适度更好?
Cont Lens Anterior Eye. 2018 Jun;41(3):252-257. doi: 10.1016/j.clae.2017.12.005. Epub 2017 Dec 6.
9
Tear film and ocular surface dysfunction in diabetes mellitus in an Indian population.印度人群中糖尿病患者的泪膜和眼表功能障碍
Indian J Ophthalmol. 2017 Apr;65(4):301-304. doi: 10.4103/ijo.IJO_939_15.
10
Ocular surface involvement in patients with neurofibromatosis type 1 syndrome.1 型神经纤维瘤病患者的眼表面受累。
Graefes Arch Clin Exp Ophthalmol. 2020 Aug;258(8):1757-1762. doi: 10.1007/s00417-020-04717-5. Epub 2020 May 9.

引用本文的文献

1
Changes in Corneal Epithelial Thickness Induced by Topical Antiglaucoma Medications.局部抗青光眼药物引起的角膜上皮厚度变化
J Clin Med. 2021 Aug 5;10(16):3464. doi: 10.3390/jcm10163464.
2
Fourier-Domain OCT Imaging of the Ocular Surface and Tear Film Dynamics: A Review of the State of the Art and an Integrative Model of the Tear Behavior During the Inter-Blink Period and Visual Fixation.眼表和泪膜动力学的傅里叶域光学相干断层扫描成像:现状综述及眨眼间隔期和视觉注视期间泪液行为的综合模型
J Clin Med. 2020 Mar 2;9(3):668. doi: 10.3390/jcm9030668.
3
A study of refractory cases of persistent epithelial defects associated with dry eye syndrome and recurrent corneal erosions successfully treated with cyclosporine A 0.05% eye drops.

本文引用的文献

1
A Simple Novel Technique of Infrared Meibography by Means of Spectral-Domain Optical Coherence Tomography: A Cross-Sectional Clinical Study.一种基于谱域光学相干断层扫描的新型简易红外睑板腺造影技术:一项横断面临床研究。
PLoS One. 2016 Oct 31;11(10):e0165558. doi: 10.1371/journal.pone.0165558. eCollection 2016.
2
Evaluation of the adhesive properties of the cornea by means of optical coherence tomography in patients with meibomian gland dysfunction and lacrimal tear deficiency.通过光学相干断层扫描评估睑板腺功能障碍和泪液缺乏患者角膜的黏附特性。
PLoS One. 2014 Dec 23;9(12):e115762. doi: 10.1371/journal.pone.0115762. eCollection 2014.
3
一项关于使用0.05%环孢素A滴眼液成功治疗与干眼症和复发性角膜糜烂相关的顽固性持续性上皮缺损病例的研究。
Drug Des Devel Ther. 2019 Jun 19;13:2001-2008. doi: 10.2147/DDDT.S207453. eCollection 2019.
4
Optical coherence tomography in forensic sciences: a review of the literature.法医学中的光学相干断层扫描:文献综述
Forensic Sci Med Pathol. 2019 Sep;15(3):445-452. doi: 10.1007/s12024-019-00136-z. Epub 2019 Jul 18.
Molecular mechanisms of fluoride toxicity.
氟化物毒性的分子机制。
Chem Biol Interact. 2010 Nov 5;188(2):319-33. doi: 10.1016/j.cbi.2010.07.011. Epub 2010 Aug 3.
4
Fluoride-induced cyclooxygenase-2 expression and prostaglandin E2 production in A549 human pulmonary epithelial cells.氟化物诱导A549人肺上皮细胞中环氧化酶-2的表达及前列腺素E2的产生。
Toxicol Lett. 2009 Aug 10;188(3):180-5. doi: 10.1016/j.toxlet.2009.04.007. Epub 2009 Apr 17.
5
Health effects of occupational exposure to fluorine and its compounds in a small-scale enterprise.小型企业中职业接触氟及其化合物对健康的影响
Ind Health. 2006 Jan;44(1):64-8. doi: 10.2486/indhealth.44.64.
6
Fluoride poisoning: a puzzle with hidden pieces.氟中毒:一个谜团重重的难题。
Int J Occup Environ Health. 2005 Oct-Dec;11(4):404-14. doi: 10.1179/oeh.2005.11.4.404.
7
LUNG CANCER IN A FLUORSPAR MINING COMMUNITY. I. RADIATION, DUST, AND MORTALITY EXPERIENCE.萤石矿开采社区的肺癌。I. 辐射、粉尘与死亡经历。
Br J Ind Med. 1964 Apr;21(2):94-109. doi: 10.1136/oem.21.2.94.
8
A new classification of ocular surface burns.眼表烧伤的一种新分类。
Br J Ophthalmol. 2001 Nov;85(11):1379-83. doi: 10.1136/bjo.85.11.1379.
9
Hydrofluoric acid burns of the eye.眼部氢氟酸灼伤
J Occup Med. 1983 Jun;25(6):447-50. doi: 10.1097/00043764-198306000-00008.
10
Fatal hydrofluoric acid cutaneous exposure with refractory ventricular fibrillation.致命的氢氟酸皮肤暴露伴顽固性心室颤动。
J Burn Care Rehabil. 1987 May-Jun;8(3):216-9. doi: 10.1097/00004630-198705000-00009.