鸡蛋白牛初乳补充剂可减轻轻/中度新冠肺炎症状：一项随机对照试验。
Hen egg white bovine colostrum supplement reduces symptoms of mild/moderate COVID-19: a randomized control trial.
作者信息
Mann Jaclyn Kelly, Reddy Tarylee, van der Stok Mary, Ngubane Ayanda, Mulaudzi Takalani, Mchunu Nobuhle, Nevhungoni Portia, Manickchund Nithendra, Manickchund Pariva, Louise Cairns Chelline Helena, Govender Vaneshree, Ndung'u Thumbi, Suleman Moosa Mahomed Yunus, Gosnell Bernadett Isabel
机构信息
HIV Pathogenesis Programme, University of KwaZulu-Natal, Durban, 4001, South Africa.
Biostatistics Research Unit, South African Medical Research Council, Durban, 4091, South Africa.
出版信息
Future Sci OA. 2023 Jul 20;9(8):FSO882. doi: 10.2144/fsoa-2023-0024. eCollection 2023 Sep.
AIM
The ability of a hen egg white bovine colostrum supplement to prevent severe COVID-19 was tested in a double-blind randomized control study.
METHODS
Adults with mild/moderate COVID-19, risk factors for severe disease, and within 5 days of symptom onset were assigned to the intervention (n = 77) or placebo (n = 79) arms. Symptoms were documented until day 42 post-enrollment and viral clearance was assessed at 11-13 days post-symptom onset.
RESULTS
One participant developed severe COVID-19. The severe-type symptom score was lower in the active arm at 11-13 days post-symptom onset (p = 0.049). Chest pain, fever/chills, joint pain/malaise, and sore throat were significantly less frequent in the active arm. No differences in viral clearance were observed.
CONCLUSION
The intervention reduced symptoms of mild/moderate COVID-19.
CLINICAL TRIAL REGISTRATION
DOH-27-062021-9191 (South African National Clinical Trials Register).
目的
在一项双盲随机对照研究中测试了补充鸡蛋白牛初乳预防重症新型冠状病毒肺炎（COVID-19）的能力。
方法
将患有轻/中度COVID-19、有重症疾病风险因素且症状出现后5天内的成年人分配至干预组（n = 77）或安慰剂组（n = 79）。记录症状直至入组后42天，并在症状出现后11 - 13天评估病毒清除情况。
结果
一名参与者发展为重症COVID-19。在症状出现后11 - 13天，干预组的重症型症状评分较低（p = 0.049）。干预组中胸痛、发热/寒战、关节疼痛/不适和喉咙痛的发生频率显著较低。未观察到病毒清除方面的差异。
结论
该干预措施减轻了轻/中度COVID-19的症状。
临床试验注册
DOH-27-062021-9191（南非国家临床试验注册）。
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