Lab of Chemical Biology and Molecular Drug Design, College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, 310014, China.
Institute of Drug Development & Chemical Biology, Zhejiang University of Technology, Hangzhou, 310014, China.
Curr Med Chem. 2024;31(30):4826-4849. doi: 10.2174/0929867331666230825104254.
Cancers are a huge threat to human life and health. Every year, many people suffer and die from various cancers, and numerous resources have been used to combat cancer. Due to several disadvantages of anticancer agents, such as drug-induced side effects, drug resistance, etc., there are still wide gaps in their ability to conquer cancer. Therefore, there is an urgent need to discover and develop many novel chemotypes to suppress cancer. In this review, we mainly focus on the anticancer potency of two representative sorts of carbazole-based compounds: carboline derivatives and diazacarbazole derivatives. Diazacarbazole derivatives, which have not been fully explored yet, might bring us a new vision and a valuable opportunity for overcoming the enormous hurdle we are now facing in the cancer campaign. We also provide several synthetic approaches for constructing the critical skeletons of the carbazole-based tricyclic compounds.
癌症是对人类生命和健康的巨大威胁。每年，许多人因各种癌症而遭受痛苦和死亡，大量资源都被用于对抗癌症。由于抗癌药物存在一些缺点，如药物诱导的副作用、耐药性等，它们在攻克癌症方面的能力仍存在很大差距。因此，迫切需要发现和开发许多新型的化学结构来抑制癌症。在这篇综述中，我们主要关注两种具有代表性的咔唑类化合物的抗癌活性：卡洛啉衍生物和二氮杂咔唑衍生物。二氮杂咔唑衍生物尚未得到充分探索，可能为我们提供新的视角和克服癌症研究中面临的巨大障碍的宝贵机会。我们还提供了几种构建咔唑三环化合物关键骨架的合成方法。
